Histologic and receptor analysis of primary and secondary vestibulodynia and controls: a prospective study

Martha F. Goetsch, Terry K. Morgan, Veselina B Korcheva, Veselina Korcheva, Hong Li, Dawn Peters, Catherine M. Leclair
American journal of obstetrics and gynecology · 2010 · vol. 202(6) , pp. 614.e1–614.e8 · doi:10.1016/j.ajog.2010.01.028 · PMID:20430353 · W1987801318
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This prospective study analyzed the histologic features and receptor expression in vulvar tissue from women with primary vestibulodynia, secondary vestibulodynia, and healthy controls.

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Abstract

OBJECTIVE: The objective of the study was to assess the association between hormone receptor densities, pain nerves, and inflammation in vestibulodynia patients. STUDY DESIGN: In a prospective study, tender and nontender biopsies from 10 primary and 10 secondary vestibulodynia patients were compared with biopsies in 4 nontender controls. Hormone receptors were evaluated using immunohistochemistry for estrogen receptor-alpha and -beta, androgen, and progesterone receptors. Inflammation, nerves, and mast cells were assessed histologically. Statistical analysis was by Fisher's exact test, analysis of variance, paired Student t test, and Wilcoxon rank test. RESULTS: Tender sites from primary vestibulodynia had increased nerve density compared with secondary and control biopsies (P = .01). Tender sites in secondary vestibulodynia had more lymphocytes than tender primary sites and control biopsies (P < .0001). Mast cells were increased in tender sites compared with nontender and controls. There were no differences in hormone receptor expression. CONCLUSION: Markers of inflammation differed between primary and secondary vestibulodynia and controls.

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MeSH descriptors

Vulvodynia Adult Analysis of Variance Estradiol Estradiol Estrogen Receptor alpha Estrogen Receptor alpha Estrogen Receptor beta Estrogen Receptor beta Female Humans Immunohistochemistry Inflammation Inflammation Inflammation Mast Cells Mast Cells Mast Cells Middle Aged Progesterone

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