Poor response to danazol in hemophilia
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Danazol treatment in hemophilia patients showed minimal and questionable benefits alongside significant side effects including muscle cramps, rash, and hepatic dysfunction.
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Abstract
We gave danazol (600 mg/day orally for 14 days) to eight adults with mild or moderate hemophilia A, one with severe hemophilia A, and one with moderate hemophilia B. In the patient with severe hemophilia A, the levels of factor VIII two to four days after an infusion of factor VIII concentrate were higher than expected, suggesting a prolonged half-life. In one patient with mild hemophilia A, a questionable slight increase in factor VIII was noted at the end of the study. No change was seen in factor levels of other subjects. Therapy was terminated early, at eight days, in a patient who developed severe muscle cramps, and at ten days in a patient with a severe rash. Another patient developed hepatic dysfunction three days after completing the 14-day trial. In this trial, the side effects of danazol outweighed its meager and questionable benefits.
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References (2)
- doi:10.1182/blood.v49.5.793.793 via openalex
- doi:10.1056/nejm198306093082305 via openalex
Cited by (7)
- Danazol therapy in factor X deficiency 2001
- Effect of danazol on clotting factor levels, bleeding incidence, factor infusion requirements, and immune parameters in hemophilia 1986
- Hepatitis Associated with Danazol 1986
- Danazol fails to increase factor VIII or IX levels in a double‐blind crossover study of patients with haemophilia A and B 1986
- Danazol for Lupus Thrombocytopenia 1985
- Danazol in Hemophilia 1985
- Danazol in Hemophilia-Reply 1985
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