Danazol therapy in factor X deficiency

Sanjay Mukhopadhyay, Renu Saxena, Rajesh Kashyap, V. P. Choudhry
In: Haemophilia · 2001 · vol. 7(5) , pp. 504–506 · doi:10.1046/j.1365-2516.2001.00541.x · PMID:11554940 · W2044648028
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This paper reports a case of factor X deficiency presenting with both bleeding and thrombosis, successfully treated with danazol, and reviews the role of danazol in coagulopathies.

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Abstract

Factor X (FX) deficiency is a rare coagulation disorder that usually presents with bleeding manifestations and is treated with fresh frozen plasma or prothrombin complex concentrates. We report a case of FX deficiency in which the patient presented with bleeding as well as thrombosis. The patient responded to Danazol and relapsed when the drug was stopped. The occurrence of thrombosis in FX deficiency and the role of Danazol in coagulopathies are reviewed.

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