Danazol for Lupus Thrombocytopenia
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Danazol therapy increased platelet counts in three lupus thrombocytopenia patients refractory to prednisone, though two experienced a reversible maculopapular rash.
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Abstract
Danazol therapy was used in the treatment of three consecutive patients with lupus-associated thrombocytopenia refractory to high-dose prednisone therapy (two patients) or in whom high-dose prednisone therapy was considered contraindicated (one patient). Treatment was associated in each case with an increase in platelet count but was complicated in two of three patients by the development of a diffuse maculopapular rash that promptly resolved following discontinuation of danazol therapy. Retreatment of one patient with danazol was associated with immediate recurrence of the rash. We suggest that danazol therapy deserves further evaluation in the treatment of lupus-associated thrombocytopenia, but advise that patients be carefully monitored for rash.
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Too few in-corpus citations on either side for a chart; here are the lists.
Cites (2)
- Preliminary observations on danazol therapy of systemic lupus erythematosus: effects on DNA antibodies, thrombocytopenia and complement. 1983
- Poor response to danazol in hemophilia 1985
Cited by (4)
References (6)
- Poor response to danazol in hemophilia via openalex
- Preliminary observations on danazol therapy of systemic lupus erythematosus: effects on DNA antibodies, thrombocytopenia and complement. via openalex
- doi:10.1056/nejm198306093082306 via openalex
- doi:10.7326/0003-4819-102-3-325 via openalex
- doi:10.1002/art.1780251101 via openalex
- doi:10.1097/00000658-197801000-00010 via openalex
Cited by (4)
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- last seen: 2026-05-11T03:39:08.368949+00:00
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