Clear cell carcinoma derived from an endometriosis focus in a scar after a caesarean section--a case report and literature review

Zuzanna Dobrosz, Piotr Paleń, Rafał Stojko, Stojko R, Paweł Właszczuk, Paweł Właszczųk, Anna Niesłuchowska-Hoxha, Niesłuchowska-Hoxha A, Piechuta-Kośmider I, Ilona Piechuta-Kośmider
Ginekologia polska · 2014 · vol. 85(10) , pp. 792–5 · PMID:25546933 · W2395132764
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This report details a case of clear cell carcinoma arising from an endometriosis focus in a cesarean section scar, a rare occurrence with a significant time lag between surgery and diagnosis.

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Abstract

Endometriosis is defined as the occurrence of endometrial glands and endometrial stromal cells outside their typical localization within the uterus. Malignant transformation of endometriosis foci in a scar after a caesarean section (cc) is very rare--until 2013 (in a span of 40 years), about 40 such cases have been described. In our article, we describe a case of a 42-year-old woman with a tumour localized in a scar after a caesarean section. The tumour was diagnosed as clear cell carcinoma derived from an endometriosis focus. The long time interval--17 years in average (from 3 to 39 years) between the surgery (cesarean section in most cases) and the tumor diagnosis is characteristic. In the case we describe, the patient was diagnosed 16 years after the endometriosis focus in the scar had arised. Even though endometriosis is a benign lesion, it has many features distinctive for invasive carcinoma; it may itself undergo a malignant transformation as well as increase the risk of endometrial carcinoma or clear cell ovarian carcinoma. Maybe in future, more exhaustive studies will allow establishing a therapeutic protocol in patients with extra-ovarian malignant transformation of endometriosis foci.

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Condition tags

endometriosis

MeSH descriptors

Adenocarcinoma, Clear Cell Carcinoma, Endometrioid Cesarean Section Cicatrix Endometriosis Adenocarcinoma, Clear Cell Adenocarcinoma, Clear Cell Adenocarcinoma, Clear Cell Adenocarcinoma, Clear Cell Adult Adult Carcinoma, Endometrioid Carcinoma, Endometrioid Carcinoma, Endometrioid Carcinoma, Endometrioid Cesarean Section Cesarean Section Cicatrix Cicatrix Cicatrix

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

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