Genetics of endometriosis.

A M Di Blasio, Francesco Santullo, S Di Francesco, A Abbiati, Annalisa Abbiati, Paola Viganò, P Viganò
Minerva ginecologica · 2005 · vol. 57(3) , pp. 225–36 · PMID:16166932 · W2464282389
article OA: closed CC0 ⤵ 5 in-corpus citations
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This paper discusses the genetic basis of endometriosis as a multifactorial polygenic disorder and the ongoing efforts to identify susceptibility genes using advanced molecular techniques.

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Abstract

UNLABELLED: Endometriosis is a multifactorial disease that can affect up to 10-15% of women in their reproductive age. Epidemiological studies indicate that it is a polygenic disorder with recurrence risks in first-degree relatives of about 5-7%. Thus, the present aim of different research groups is to identify genetic variations in obvious candidate gene that could be associated with an increased susceptibility to endometriosis. The great advancement in molecular biology techniques make this task certainly possible, although particular attention needs to be paid to the study design in order to achieve reliable RESULTS: The data obtained by such studies will allow to expand our knowledge on the pathogenesis of the disease and, more importantly, to develop individualized therapies and prevention strategies to apply at high-risk populations.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Alleles Chromosomes, Human, Pair 9 Chromosomes, Human, Pair 9 Endometriosis Female Humans Metabolic Detoxication, Phase I Metabolic Detoxication, Phase I Metabolic Detoxication, Phase II Metabolic Detoxication, Phase II Risk Factors UTP-Hexose-1-Phosphate Uridylyltransferase UTP-Hexose-1-Phosphate Uridylyltransferase

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

Cited by (5)

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