Oily contrast medium as a therapeutic agent for infertility because of mild endometriosis

Y Sawatari, Sawatari Y, Yoshiharu Sawatari, Takahisa Horii, T Horii, Horii T, Hoshiai H, H Hoshiai, Hiroshi Hoshiai
Fertility and sterility · 1993 · vol. 59(4) , pp. 907–11 · doi:10.1016/s0015-0282(16)55880-4 · PMID:8384577
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Lipiodol administration increased pregnancy rates in mice with simulated endometriosis, potentially by increasing prostaglandin F2 alpha and reducing interleukin-1 beta levels.

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Abstract

OBJECTIVE: To investigate the utility of using oily contrast medium (Lipiodol; Kodama, Tokyo, Japan) to treat infertility because of mild endometriosis. DESIGN: Macrophages in the peritoneal cavity of ICR mice (Japan SLC, Shizuoka, Japan) were induced by administering OK-432 to simulate the condition of the peritoneal cavity of patients with mild endometriosis, and the pregnancy rate was examined after administration of Lipiodol and/or danazol (Bonzol; Tokyo Tanabe, Tokyo, Japan). Interleukin-1 beta (IL-1 beta), prostaglandin (PG)F2 alpha (PGF2 alpha), and PGE2 levels in the supernatant were measured after incubating macrophages of mice with Lipiodol and/or danazol. MAIN OUTCOME MEASURES: Pregnancy rate (PR) and IL-1 beta, PGF2 alpha, and PGE2 levels. RESULTS: The PR of the Lipiodol group was significantly increased compared with that in control mice. Prostaglandin F2 alpha level in the supernatant was significantly increased, whereas that of IL-1 beta was reduced after incubation with Lipiodol. CONCLUSIONS: Lipiodol may elevate PGF2 alpha level and reduce IL-1 beta level in the peritoneal cavity, and this drug may increase the PR of ICR mice.

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Condition tags

endometriosisinfertility

MeSH descriptors

Endometriosis Infertility, Female Iodized Oil Animals Animals Cells, Cultured Cells, Cultured Danazol Danazol Danazol Dinoprost Dinoprost Dinoprost Dinoprostone Dinoprostone Dinoprostone Endometriosis Endometriosis Female Female

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (11)

Cited by (1)

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