Tumor necrosis factor in peritoneal fluid of women undergoing laparoscopic surgery

Eisermann J, J Eisermann, M J Gast, Gast MJ, Pineda J, J Pineda, R R Odem, Odem RR, J L Collins, Collins JL
Fertility and sterility · 1988 · doi:10.1016/s0015-0282(16)60185-1 · PMID:2971579
other OA: closed public-domain-us ⤵ 1 in-corpus citation
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Analysis of peritoneal fluid from 74 women revealed significantly elevated tumor necrosis factor levels and positivity rates in those with moderate or severe endometriosis compared to women with normal pelvic anatomy.

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Abstract

The level of tumor necrosis factor (TNF) in peritoneal fluid (PF-TNF) of 74 women undergoing laparoscopy was determined. The difference between the mean concentration of PF-TNF of women with normal pelvic anatomy and women with moderate or severe endometriosis was significant (P less than 0.01). The proportion of PF-TNF-positive women with PID and those with moderate or severe endometriosis was also significantly higher when compared to women with normal pelvic anatomy (P less than 0.05; P less than 0.02). The proportion of PF-TNF positive women among nulligravid and nulliparous women was significantly higher than that of women with two or more pregnancies (P less than 0.01) and two or more deliveries (P less than 0.005). These results indicate that the presence of PF-TNF is associated with primary infertility and endometriosis.

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Condition tags

endometriosisinfertility

MeSH descriptors

Ascitic Fluid Tumor Necrosis Factor-alpha Adolescent Adult Antibodies Ascitic Fluid Cell Line Endometriosis Endometriosis Endometriosis Female Humans Laparoscopy Tumor Necrosis Factor-alpha

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