ACS omega

Natural polyphenolics, more specifically flavonoids and derivatives, constitute chemically versatile scaffolds with a broad biological potential. In this study, different flavonoid derivatives (1-37) were assessed for cytotoxicity in Ishika…

Bisphenol A (BPA), an endocrine-disrupting chemical frequently detected in follicular fluid (FF), has been implicated in ovarian reserve dysfunction. However, data on the presence of its structural analogues within ovarian follicles remain …

Lycopene, a naturally occurring carotenoid predominantly found in tomatoes and other red fruits, has attracted growing scientific interest due to its potent bioactive properties and wide-ranging therapeutic potential. This mini-review delve…

One-class classifier (OCC) models are widely applied to solve classification problems where control or class modeling from a target class is necessary. In this study, OCC models such as Data Driven Soft Independent Modeling of Class Analogy…

Cannabidiol (CBD), a major nonpsychoactive phytocannabinoid derived from Cannabis sativa L., has recently gained prominence for its broad pharmacological profile and emerging applications in regenerative medicine. Beyond its well-establishe…

Endometriosis is a condition affecting approximately 10% of reproductive-age women in which endometrial tissue is found in locations outside the uterus, often causing debilitating symptoms. Aromatase, an enzyme that also plays a key role in…

Assisted reproductive technologies (ART) have revolutionized the field of reproductive medicine, offering hope to millions of individuals and couples facing fertility problems. From artificial insemination to cutting-edge gene editing techn…

Diabetic retinopathy (DR) is a major cause of vision impairment, with diabetic retinal neurodegeneration (DRN) identified as an early pathological feature. Although dopamine (DA) has demonstrated protective effects in various neurodegenerat…

Gold nanoparticles (AuNPs) are renowned for their unique optical, electronic, and biocompatible properties, making them ideal for applications in drug delivery, diagnostics, imaging, and materials science. With green chemistry-based biologi…

The QuEChERS (Quick, Easy, Cheap, Effective, Rugged, and Safe) technique has gained wide acceptance worldwide due to its efficiency in multiresidue pesticide analysis across diverse matrices. Continuous improvements have further enhanced it…

Delving into the intricate role of phytonutrients is paramount to effectively preventing and treating chronic diseases. Phytonutrients are "plant-based nutrients" that positively affect human health. Phytonutrients perform primary therapeut…

Tetrahydropalmatine (THP) is the major bioactive alkaloid in Stephania rotunda Lour. (Menispermaceae) with well-known pharmacological properties, such as antiaddiction, antitumor, and neuroprotective activities. In this study, a novel ultra…

Polymeric nanoparticles (NPs) have shown great promise as highly modifiable platforms that can be applied across many different disease states. They are advantageous because they can encapsulate a range of hydrophobic and hydrophilic cargoe…

Cancer, a life-disturbing and lethal disease with a high global impact, causes significant economic, social, and health challenges. Breast cancer refers to the abnormal growth of cells originating from breast tissues. Hormone-dependent form…

The uterus, a vital organ in the female reproductive system, nurtures and supports developing embryos until maturity. This study focuses on addressing uterine related problems by creating a nanofibrous scaffold to regenerate uterine myometr…

Curcumin has been credited with a wide spectrum of pharmacological properties for the prevention and treatment of several chronic diseases such as arthritis, autoimmune diseases, cancer, cardiovascular diseases, diabetes, hemoglobinopathies…

Daidzein (DDZ) is a well-known nutraceutical supplement belonging to the class of isoflavones. It is isolated from various sources such as alfalfa, soybean, and red clover. It demonstrates a broad array of pharmacological/beneficial propert…

The most common female endocrinopathy, polycystic ovarian syndrome (PCOS), generally affects women of childbearing age. Hippophae rhamnoides L. has been traditionally used to improve menstrual cyclicity. Gas chromatography by flame ionizati…

Endometriosis (EM) is a hormone-dependent gynecological disease associated with chronic pelvic pain and altered immuno-inflammatory processes. It shares some cancer-like characteristics such as increased proline biosynthesis and activated g…

Designing molecules for drugs has been a hot topic for many decades. However, it is hard and expensive to find a new molecule. Thus, the cost of the final drug is also increased. Machine learning can provide the fastest way to predict the b…

Chronic wound infections caused by antibiotic-resistant bacteria have become a global health concern. This is attributed to the biofilm-forming ability of bacteria on wound surfaces, thus enabling their persistent growth. In most cases, it …

The urge for sensitive, facile, minimally invasive, and fast detection method of CA-125, a significant and crucial biomarker in ovarian malignancy, is currently substantial. This paper describes the detailed construction and characterizatio…

The objective of this study is to investigate the influence of the thyroid autoantibodies on the protein expression in follicular fluid and the clinical outcome of assisted reproductive technology. A total of 602 patients treated for infert…

Tetrahydrobiopterin (BH4) is a cofactor in the production of various signaling molecules including nitric oxide, dopamine, adrenaline, and noradrenaline. BH4 levels are critical for processes associated with cardiovascular function, inflamm…

Synthetic routes to potent bicyclic nonsteroidal sulfamate-based active-site-directed inhibitors of the enzyme steroid sulfatase (STS), an emerging target in the treatment of postmenopausal hormone-dependent diseases, including breast cance…