Clinical pharmacology and therapeutics

Maternal health remains a critical global concern, particularly in underserved populations and in low- and middle-income countries where access to safe and effective therapeutics is limited. Despite the use of medications by most women duri…

Despite widespread rhFSH use in infertile women undergoing ART, real-world comparative data on its effectiveness and safety across different rhFSH types remain limited. Using the HIRA claims database, we included 10,684 women aged 20-39 wit…

Gene expression networks associated with placebo effects are understudied; in this study, we identified transcriptomic profiles associated with placebo responsivity. Participants suffering from chronic pain underwent a verbal suggestion and…

As drug development is extremely expensive, the identification of novel indications for in-market drugs is financially attractive. Multiple algorithms are used to support such drug repurposing, but highly reliable methods combining simulati…

Inflammatory bowel disease (IBD) is a chronic immune-mediated inflammatory disease of the intestine that includes both Crohn's disease and ulcerative colitis, and afflicts nearly 1 million people throughout North America. As our understandi…

Methods of administration side effects and pharmacology of 4 proges tins employed in treating endometriosis were presented. 17-alpha-hydrox yprogesterone caproate (Delalutin) 17-alpha-ethinyl-17-hydroxy-5-10-est ren-3-one (norethynodrel) wi…

The treatment of endometriosis with danazol or lynestrenol decreased cholesterol content of plasma high-density lipoproteins by 50% and 32%. There were simultaneous increases in low-density lipoprotein cholesterol content of 51% and 19%. We…

Although the progestins in common play an integral role in the endogenous synthesis of all steroids, precise definition of what a progestin is is nonetheless difficult, since the progestational steroids are ubiquitous steroids of multiple s…