JAMA: The Journal of the American Medical Association

Dr Daley : Mrs B is a 32-year-old paralegal. Married for 5 years to Mr B, a 32-year-old manager, they have been trying to conceive since 1992. They are both members of a health maintenance organization and live in Massachusetts, where healt…

ESTROGEN and agents that mimic it appear to be more pervasive and problematic than ever suspected. Estrogen has long been implicated in diseases like breast cancer and endometriosis that primarily affect women. New evidence suggests that es…

To the Editor. —Dr Hankinson and colleagues 1 have reported that tubal ligation, and perhaps hysterectomy, may substantially reduce risk of ovarian cancer. How this risk reduction might be mediated is unknown, and various mechanisms have be…

To the Editor. —Danazol is an androgenic compound used in the treatment of endometriosis, benign cystic breast disease, and some hematologic disorders. Danazol therapy has been implicated in the pathogenesis of pseudotumor cerebri in some p…

Human immunodeficiency virus (HIV)-related thrombocytopenia has been well described and requires therapy in about one half of the patients. Conventional modes of therapy with prednisone, danazol, immunoglobulin, and/or splenectomy have not …

Pelvic inflammatory disease (PID) is one of the most widespread and debilitating diseases affecting women today. To calculate the economic costs of PID and PID-associated ectopic pregnancy and infertility in the United States, we analyzed d…

Danazol, an attenuated androgen, was given intermittently in three patients with hemophilia A. The rise in factor VIII activity with danazol treatment was associated with a fivefold decrease in hemorrhagic episodes and plasma concentrate pr…

Danazol is a 2,3-isoxazol derivative of 17 α-ethinyl testosterone; it is known to be an anabolic steroid with mild androgenic activity. The administration of the drug is associated with raised plasma levels of several proteins including pre…

To the Editor.— In a recent article Garewal et al1demonstrated that danazol, an attenuated androgen, given at a dose of 600 mg daily for eight to 14 weeks, is not useful in the treatment of factor VIII—deficient and factor IX—deficient hemo…

Danazol was given orally at a dose of 600 mg/day to six hemophiliacs for eight to 14 weeks. All patients showed a significant decrease in activated partial thromboplastin time (APTT) beginning with the first measurement (two weeks) and pers…

MATERNAL vernix caseosa peritonitis is an unusual complication of pregnancy. We report a case diagnosed in a woman who had premature rupture of the fetal membranes. Uterine-tubal reflux, whereby amniotic fluid gained access to the peritonea…

To the Editor.— We wish to announce the birth of a healthy infant to an infertile nulligravid woman following nonsurgical recovery and transfer of an in vivo fertilized donated ovum.1,2 The infertile recipient, a woman in her 30s with an ei…

Short-term administration of the synthetic androgenic hormone, danazol, allowed nine of ten patients with hemophilia to cut down their use of factor VIII or IX concentrate in recent studies. A report of the work was given at the recent meet…

"NATURAL" foods and herbal medicines have gained substantial popularity in the United States during the past two decades. These products often are assumed to be free of toxic side effects and are used in an effort to improve general health …

THE TECHNIQUE of radioimmunoassay (RIA) is currently the most popular method for measurement of hormone levels in plasma or serum. Radioimmunoassay combines excellent sensitivity with precision and freedom from interference. However, subtle…

To the Editor.— The articles by Chapman et al (242:1877; 1882, 1979) and the one by Sutcliffe (242:1898, 1979) provide lucid descriptions of women who have experienced great emotional trauma as a result of having a potentially fatal disease…

To the Editor.— Penny W. Budoff, MD (241:2713, 1979), has suggested that mefenamic acid, by virtue of its ability to inhibit prostaglandin activity, in addition to its ability to inhibit prostaglandin synthesis, may offer the advantage of a…

Telephone interviews with 12 patients (11 had Progestasert IUDs; 1 had copper 7 IUD), who were suffering from dysmenorrhea, were conducted to determine the effects of mefenamic acid in dysmenorrheic patients using IUD. Average duration of I…

To the Editor.— Regarding the discusion in QUESTIONS AND ANSWERS (239:351, 1978) concerning a patient with hemoptysis during orgasm, we would like to share the following case. Report of a Case.— A 34-year-old woman was referred for evaluati…

15 patients (21-32 years) suffering from post ill amenorrhea-galactorrhea (PPAG), which was associated with an alternation in the secretion of prolactin and absence of cyclic gonadotropins, were studied with in-depth interviews to determine…

Primary ovarian pregnancy is an extremely unusual form of ectopic gestation, occurring in 1:25,000 to 1:40,000 pregnancies. Most cases are diagnosed and treated in the first trimester, and have a history and findings similar to those of tub…

Bilateral ovarian enlargement with massive ascites and pregnancy occurred in a patient after two courses of clomiphene citrate (Clomid) therapy. It is likely that the patient received the second course of clomiphene during early stages of p…

THE USE OF pure crystalline progesterone which was isolated and prepared for the first time in 1934 was limited mainly in its therapy for the first 13 years to the treatment of habitual and threatened abortion. With the clinical introductio…

Histologically benign thyroid follicles have been found in lateral cervical lymph nodes of 16 patients at Memorial Hospital, New York. All were incidental findings in radical neck dissections for malignant tumors of other than thyroid origi…