Molecular reproduction and development

article 2008

XRCC4 codon 247*A and XRCC4 promoter −1394*T related genotypes but not XRCC4 intron 3 gene polymorphism are associated with higher susceptibility for endometriosis

doi:10.1002/mrd.20829 ·PMID:18246529

DNA repair systems act to maintain genome integrity in the face of replication errors, environmental insults, and the cumulative effects of age. Genetic variants in DNA repair genes such as X-ray repair cross-complementing group 4 (XRCC4) m…

article 2006

Angiotensin I‐converting enzyme insertion‐related genotypes and allele are associated with higher susceptibility of endometriosis and leiomyoma

doi:10.1002/mrd.20474 ·PMID:17186537

Endometriosis and leiomyoma display features similar to malignancy, requiring neovascularization to proliferation and growth. Altered vascular-related genes might be related to the development of endometriosis and leiomyoma. Polymorphisms o…

article 2002

Identification of the cadherin subtypes present in the human peritoneum and endometriotic lesions: Potential role for P‐cadherin in the development of endometriosis

doi:10.1002/mrd.10121 ·PMID:12112590

Endometriosis is defined as endometrial tissue outside of the uterine cavity. The pathogenesis of this common disease remains poorly understood. However, the implantation and invasion of the viable cells from retrograde menstruation into th…

other 1999

Factors controlling epidermal growth factor (EGF) gene expression in the endometrium of the mare

doi:10.1002/(SICI)1098-2795(199907)53:3<255::AID-MRD1>3.0.CO;2-D ·PMID:10369386

Previous studies showed a dramatic increase in EGF gene expression in the endometrial glands of pregnant mares around day 40 after ovulation. To investigate how the steroid hormones of pregnancy might regulate this expression, in situ hybri…