Scientific reports

Myofascial pain syndrome (MPS) is a common chronic pain condition characterized primarily by the presence of myofascial trigger points (MTrPs). While the insulin-like growth factor-1 receptor (IGF-1R) is known to be upregulated in injured m…

Despite advancements in assisted reproductive technology (ART), recurrent implantation failure (RIF) continues to pose a significant challenge to achieving pregnancy. We included 2,463 retrospective RIF patients with no gynecological and an…

The sex steroid hormones significantly impact women's physiology. Therefore, recently developed integrated exercises consisting of Bending, Roll-ups, Arm swings with loads, Crunches, Tandem walks, and Squats (BRACTS) were formulated. It was…

Purpose Electronic cigarettes (E-cigarettes) vaporize a liquid containing glycol, nicotine, and various additives, providing an alternative to traditional smoking. Although they contain only 5% of the harmful substances found in traditional…

The cause of infertility in women with endometriosis remains unclear. Elevated levels of iron in the follicular fluid (FF), potentially leading to oxidative stress, have been reported in endometriosis. In this study, we aimed to compare mar…

This study aimed to evaluate the predictive value of relative change in E2 levels during controlled ovarian stimulation (COS) on embryo development and pregnancy outcomes in assisted reproductive technology (ART). We retrospectively analyze…

To evaluate whether the Spring Festival has an effect on the outcomes of patients undergoing their first embryo transfer (ET) via in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI). We conducted a retrospective cohort study …

The association between uterine leiomyoma and migraine is unknown. This study aimed to explore the risk of uterine leiomyoma among women with migraine in reproductive age (i.e., 20-39 years). Using the Korean National Health Insurance Servi…

Little is known about modifiable risk factors for young-onset ovarian cancer, except for obesity and nulliparity. We investigated the association between non-alcoholic fatty liver disease (NAFLD) and the risk of young-onset ovarian cancer. …

Ovarian clear cell carcinoma (OCCC) is resistant to chemotherapy, with limited treatment options for advanced and recurrent disease. The prevalence of OCCC differs by region. Assessing the expression of programmed cell death ligand 1 (PD-L1…

IL-18 is a unique cytokine that exerts both pro- and anti-inflammatory effects depending on the surrounding environments. Excessive inflammation in the feto-maternal interface is thought to result in the onset of miscarriage and preterm bir…

In couples with of non-male factor infertility, prevailing discussions have focused primarily on patients undergoing fresh embryo transfer. However, whether intracytoplasmic sperm injection (ICSI) improves reproductive outcomes in patients …

Adenomyosis (AM) is characterized as a chronic and progressive disorder with limited therapeutic strategies available. Myometrial fibrosis is a prominent pathological feature of AM, yet the underlying molecular mechanisms remain elusive. Th…

This study explores the relationship between inflammatory biomarkers and the risk of endometriosis, aiming to develop a predictive model using National Health and Nutrition Examination Survey (1999-2006) data. The dataset included 4,089 fem…

Endometriosis (EMs) and recurrent miscarriage (RM) represent major reproductive health challenges. This study investigates the involvement of endothelial-mesenchymal transition (EndMT) in these conditions through integrative bioinformatics …

This study evaluated the effectiveness of intraovarian platelet-rich plasma (PRP) injection in improving ovarian response and embryo quality in IVF patients with poor embryo quality in previous controlled ovarian hyperstimulation (COH) cycl…

Document-level biomedical relation extraction (BioDocuRE) is essential for biomedical knowledge discovery, as many factual relationships between biomedical entities span multiple sentences or even the entire document. Despite recent advance…

Efficient treatment strategies for stress urinary incontinence (SUI) in elite female athletes (EFAs) are crucial for their timely return to sports. This study evaluates the effectiveness and potential drawbacks of non-ablative Er: YAG laser…

Neuropathic pain (NP) is caused by primary damage and dysfunction of nervous system, in which spinal cord injury (SCI) is a common cause of NP. Evidence shows that neuroinflammation and oxidative stress are related to the pathophysiology of…

Osteosarcoma (OS) is the most common primary malignant bone tumor. Recent evidence suggests that the novel long noncoding RNA DHRS4 antisense RNA 1 (DHRS4-AS1) serves an important role in cancer progression and metastasis. However, its func…

We aimed to evaluate the successful long-term use of dienogest for the management of pelvic pain and bleeding control in perimenopausal women with symptomatic adenomyosis using real-world data. All women aged ≥ 40 years with adenomyosis who…

Objective Endometrial lesions are a frequent complication following breast cancer, and current diagnostic tools have limitations. This study aims to develop a machine learning-based nomogram model for predicting the early detection of endom…

Abnormal uterine bleeding (AUB) represents a notable sign for benign and malignant uterine pathology. Differentiating adenomyosis from leiomyoma via hysteroscopy aids in selecting appropriate surgical or medical management. Accurate diagnos…

Diet may play a crucial role in managing endometriosis. Dietary interventions could help women with endometriosis improve their quality of life and reduce pain symptoms. The aim of this study was to examine the association between adherence…

Several biomolecules have been previously associated with unexplained infertility (uIF) in blood and uterine samples, immune cells and their secreted factors, endometrial tissue, menstrual blood, serum, and stromal cells, however they do no…