Scientific reports

Endometriosis poses diagnostic challenges. This study aimed to analyze the metabolomic profiles of plasma and peritoneal fluid samples obtained from women with endometriosis compared to controls. Our multicenter study involved sample collec…

Adenomyosis (AM) is a common and challenging disease in gynecological clinics, which adversely affects women's physical and mental health. Despite the growing number of studies, the mechanisms associated with the growth of the lesion are po…

This study aimed to identify miRNA-based biomarkers in a multi-ethnic cohort of SARS-CoV-2-infected individuals to enhance preparedness for future variants of concern. A total of 31 healthy controls and 154 infected patients were enrolled, …

Endometriosis (EMS) is a chronic gynecological condition affecting 6-10% of reproductive-age women. These lesions, albeit of benign nature, present cancer-like features, and may progress to epithelial ovarian cancer (EOC) through a multiste…

Cuproptosis, a copper-dependent distinct form of cell death, holds a critical role in tumor development. However, further investigation is needed to elucidate the impact of the cuproptosis signaling on thyroid cancer. In this study, compreh…

Currently, the treatment and prevention of multiple sclerosis (MS) continue to encounter significant challenges. Mendelian randomization (MR) analysis has emerged as a crucial research method in the pursuit of new therapeutic strategies. Ac…

Endometriosis significantly impacts women's health and fertility, with cell aging playing a crucial role in its development. This study utilized a multi-omic summary Mendelian randomization (SMR) analysis, integrating genome-wide associatio…

Endometrial receptivity is essential for successful pregnancy, and endometriosis is widely recognized as a disruptor of this process. Poor endometrial receptivity is also a key factor contributing to recurrent implantation failure. Although…

Survival analysis plays a critical role in predicting patient outcomes and guiding personalized cancer therapies. Although multi-omics data provide rich biological insights, their high dimensionality poses significant challenges for robust …

Endometriosis is a chronic inflammatory gynecologic disease characterized by the abnormal implantation of endometrial tissue outside the uterus. The inflammatory microenvironment of endometriosis is dominated by highly migratory endometriot…

Lung ischemia-reperfusion injury (LIRI) is a critical complication in thoracic surgery and transplantation, driven partly by ferroptosis. While the E3 ubiquitin ligase neural precursor cell expressed, developmentally down-regulated 4 (NEDD4…

Endocrine-active compounds (EACs) derived from anthropogenic activities and bioactive components in maternal milk influence neonatal development, a critical period for postnatal uterine morphogenesis. Here, using an ex vivo model, we invest…

Periodontitis has recently been recognized as a potential risk factor for infertility due to its adverse effect on conception, although the underlying mechanisms remain unclear. This study investigated serum IgG antibody titers against peri…

Progestogens commonly used in the clinic include levonorgestrel, etonogestrel, medroxyprogesterone, hydroxyprogesterone, progesterone, desogestrel, and megestrol. Progestogens are widely used for contraception and the treatment of endometri…

This study investigated the relationship between dyslipidemia prior to conception and the risk of preeclampsia (PE) in women pregnant by in vitro fertilization and embryo transfer (IVF-ET). The retrospective cohort study consisted of 2994 w…

The significance of multi-combination machine learning models utilizing vision transformer (VIT) features in forecasting pathological complete response (pCR) after breast cancer neoadjuvant therapy (NAT). A retrospective study was conducted…

This study evaluates the predictive value of Anti-Müllerian Hormone (AMH) levels on outcomes in medically assisted reproduction (MAR), with a focus on women of late reproductive age. AMH, produced by granulosa cells in ovarian follicles, s…

To evaluate and compare pregnancy outcomes following successful fluoroscopy-guided tubal recanalization (FGTR), focusing on spontaneous conception versus intrauterine insemination (IUI). This retrospective cohort study included 139 women ag…

The growing reliance on online communities has reshaped how individuals articulate, validate, and navigate psychological distress. However, the value of online peer support spaces remains insufficiently studied, particularly in the context …

Anhedonia, characterized by diminished motivation and pleasure sensitivity, is increasingly recognized as prevalent among patients with chronic pain. Deep Endometriosis (DE), the most severe endophenotype of the disease, is commonly present…

Primary dysmenorrhea is the most common women's health issue, affecting 90% of adolescent girls and more than 50% of menstruating women. In general, and particularly in the study area, there is a paucity of documented information on the pre…

To prevent the occurrence of a luteinizing hormone surge during assisted reproductive technology cycles, clinicians commonly utilize gonadotropin-releasing hormone (GnRH) analogues or progestin. However, there is a paucity of data directly …

Postoperative nausea and vomiting (PONV) represent significant concerns for patients undergoing surgical procedures, as these symptoms greatly impact their postoperative experience. Among female patients undergoing laparoscopic surgery, the…

Plasma proteomics provides a unique opportunity to enhance disease prediction by capturing protein expression patterns linked to diverse pathological processes. Leveraging data from 2,923 proteins measured in 53,030 UK Biobank participants,…

Emerging evidence links epigenetic modifications, oxidative stress, and trace element imbalances to the pathogenesis of Polycystic ovary syndrome (PCOS). This study investigates the interplay between these mechanisms in a rat model of PCOS …