BMC women's health

BACKGROUND: Idiopathic vulvodynia is a chronic vulvar pain condition that occurs with a high burden of disease and frustratingly low therapeutic success. Psychosomatic factors are discussed to be involved in the onset and presentation of th…

BACKGROUND: The prevalence of hereditary bleeding disorders (HBDs) in heavy menstrual bleeding (HMB) and their impact on health-related quality of life (HRQoL) remain underexplored. We investigated the HRQoL of women with non-structural HMB…

RESEARCH QUESTION: Endometriosis-related chronic pain leads to impaired health-related quality of life (HRQoL). Endometriosis surgery can improve chronic pain and HRQoL, however, pain complaints often remain and HRQoL is still lower compare…

Endometriosis is a chronic gynecological disease that can potentially develop as early as birth and can restrict the life of the patient. With the increasing prevalence of endometriosis in Germany, it has recently gained attention and prior…

BACKGROUND: Endometriosis encompasses heterogeneous lesions, primarily peritoneal and ovarian subtypes, with distinct immunological and fibrotic features. The subtype-specific roles of the immune microenvironment in pathogenesis remain uncl…

BACKGROUND: Endometriosis is a chronic inflammatory disorder frequently associated with infertility. Tumor necrosis factor-alpha (TNF-α) is involved in inflammatory pathways; however, the clinical relevance of serum TNF-α in relation to inf…

BACKGROUND: Endometriosis affects approximately 10% of reproductive-age women worldwide, with symptom burden significantly impacting quality of life. While current treatment guidelines focus primarily on hormonal and surgical interventions,…

BACKGROUND: Adenomyosis is a chronic gynecological condition associated with pain, abnormal uterine bleeding, and impaired fertility. However, little is known about the psychosocial experiences and coping strategies of individuals with aden…

BACKGROUND: Ovarian endometriosis(OEM) is a highly prevalent condition that significantly affects women’s health. Tissue-derived extracellular vesicles(Ti-EVs) contain multiple molecules that maintain intercellular communication. They parti…

OBJECTIVE: To evaluate the long-term therapeutic efficacy of uterine artery embolization (UAE) for adenomyosis and to identify independent prognostic factors associated with postoperative recurrence. METHODS: A total of 200 adenomyosis pati…

BACKGROUND: Heavy menstrual bleeding (HMB) is a common and debilitating condition in women with bleeding disorders (BD). The underlying hemostatic abnormalities in these patients often make standard treatments ineffective. Clinical manageme…

BACKGROUND: Mature cystic teratomas (MCTs) represent common ovarian germ cell neoplasms; primary uterine teratomas are exceedingly uncommon. We report an extremely rare MCT arising within a cesarean-section scar at the anterior uterine isth…

BACKGROUND: Menstrual function is sensitive to inflammatory, endocrine, and psychosocial stressors that may transiently disrupt the hypothalamic-pituitary-ovarian axis. Although menstrual disturbances have been reported during the coronavir…

BACKGROUND: Age-related diminished ovarian reserve (DOR) exhibits marked significant individual variation. Some women of advanced age with normal ovarian reserve (NOR) achieve better reproductive outcomes than age-matched DOR patients. OBJE…

OBJECTIVE: To investigate oncological and reproductive outcomes in patients with mismatch repair-deficient (MMRd) endometrial endometrioid carcinoma (EEC) or atypical endometrial hyperplasia (AEH) undergoing fertility-preserving treatment t…

OBJECTIVE: To identify risk factors for opioid use and assess the effect of opioids on women with endometriosis. DESIGN: A retrospective cohort study. SETTING: A tertiary medical center. PARTICIPANTS: Women with confirmed or suspected endom…

BACKGROUND: Laparoscopic ovarian cystectomy for endometriosis carries a substantial risk of diminished ovarian reserve. Optimal intraoperative hemostasis remains uncertain, and predictive tools for postoperative ovarian function are limited…

BACKGROUND: Ovarian autoamputation is a rare consequence of adnexal torsion. Preoperative diagnosis is challenging, and ovarian and tubal function on the affected side is rarely preserved once autoamputation has occurred. CASE: A 29-year-o…

BACKGROUND: We compared short- and long-term patient-reported satisfaction and outcomes after hysterectomy between women with and without pelvic floor dysfunction at the time of hysterectomy. METHODS: The nationwide prospective FINHYST coho…

BACKGROUND: Endometriosis is a benign chronic gynecological disease in women of reproductive age. However, patient satisfaction with medical care for endometriosis in Germany remains underresearched. Therefore, this study aims to describe t…

BACKGROUND: Müllerian duct cyst (MDC) is an uncommon congenital lesion arising from incomplete regression of the paramesonephric duct. It typically presents as a midline pelvic cystic lesion and is often asymptomatic, making preoperative di…

OBJECTIVE: To compare the efficacy of letrozole (LT) versus clomiphene citrate (CC) for ovulation induction (OI) in women with polycystic ovary syndrome (PCOS), with emphasis on phenotypic variation and hyperandrogenism severity. METHODS: I…

BACKGROUND: Endometriosis is a common estrogen-dependent disorder that typically affects women of reproductive age and generally resolves following menopause. This report describes a rare case of postmenopausal bladder endometriosis (BE) oc…