PloS one

The objective of this study was to determine the relationship between strict morphology as assessed on the initial semen analysis during fertility workup and pregnancy rates after intrauterine insemination. This is a retrospective study of …

INTRODUCTION: To evaluate the effect of melatonin supplementation on sleep quality and pelvic pain in infertile women with endometriosis and sleep disturbances. MATERIALS AND ANALYSIS: A randomized, triple-blind, placebo-controlled trial w…

BACKGROUND: The relationship between COVID-19 vaccines and menstrual disturbance is unclear, in part because researchers have measured different outcomes (e.g., delays vs. changes to cycle length) with various study designs. Menstrual disru…

Previous abdominal surgery (PAS) increases risk of small bowel obstruction (SBO) due to adhesions, and appendectomy (appy) is an independent risk factor for abdominal adhesion-related complications. Peritoneal inflammation, e.g., acute appe…

BACKGROUND: Primary dysmenorrhea (PD), common in women below 25 years, occurs as pain in the absence of any identifiable pelvic pathology. Menstrual tracking applications (MTAs) may help women manage their PD symptoms. No systematic assessm…

BACKGROUND: Endometriosis-related pain duration and burden are associated with poorer psychological well-being and health-related quality of life (HQoLife). This study aimed to compare the relative burdens of 4 different non-menstrual pelvi…

BackgroundThe oocyte retrieval is a critical step in assisted reproductive technologies, including in vitro fertilization and fertility preservation. Despite evolving techniques, the optimal aspiration pressure during retrieval remains deba…

BACKGROUND: Surgery remains the gold standard for management of endometriosis, offering significant improvement in patient pelvic pain and quality of life (QoL). Postoperative tissue adhesions can however diminish these benefits, limiting t…

Currently, the clitoris is considered to exist solely for sexual pleasure. This prospective, single-centre pilot study focuses on and evaluates an alternative function of the clitoris; pain relief during pregnancy and childbirth. Conducted …

Computed tomographic colonography (CTC) is crucial for colorectal cancer screening and secondary examinations, often revealing extracolonic findings with unclear significance. This study retrospectively evaluated the impact of such findings…

BACKGROUND: Symptoms frequently associated with endometriosis affect quality of life (QoL). Our aim investigated the hypothesis that cluster analysis can be used to identify homogeneous phenotyping subgroups of women according to the burden…

In mammals, insulin-like peptide 3 (INSL3) and its cognate receptor (RXFP2) are reported to be essential regulators of male reproductive physiology. It is also believed that INSL3/RXFP2 signaling has a role in female ovarian function and fo…

INTRODUCTION: Previous reports have noted associations between infertility in women and increased risk of cardiovascular disease (CVD) events in later life. However, reports conflict regarding the associations between infertility and CVD ri…

BACKGROUND: Sarcopenia is a prognostic factor in patients with hepatocellular carcinoma (HCC). However, the mechanism underlying sarcopenia development in these patients remains unclear. The chemokine interferon-gamma-induced protein 10/C-X…

PURPOSE: To explore how clusters of motivational regulations, self-determination, and basic psychological needs (BPNs) relate to physical exercise participation in women with endometriosis. METHODS: This cross-sectional online study includ…

BACKGROUND: Globally, around 30% of people live with long-term ('chronic') pain, with known impact on wellbeing, economic and social lives. Despite increasing attention to contextual and psychosocial aspects of pain, there remains need to u…

ObjectiveThis study aimed to investigate the independent and synergistic effects of social isolation and multidimensional biomarkers (cardiovascular, metabolic, renal, muscular, and frailty) on physical dysfunction in middle-aged and older …

AIM: Postural orthostatic tachycardia syndrome (POTS) is a disorder with cardiovascular autonomic dysfunction where multiple and variable symptoms are common, including those from the peripheral and enteric nervous systems. We aimed to inve…

INTRODUCTION: Endometriosis is a chronic disease associated with stigmatisation and delayed diagnoses. In order to create or improve positive healthcare encounters for patients, this study aimed to explore the experiences of women with endo…

BACKGROUND: Early spontaneous abortion (ESA) is one of the most common clinically recognized pregnancy complications. While multiple factors such as embryo abnormalities and maternal conditions may contribute to ESA, early identification an…

BACKGROUND: Induction of labour (IOL) is a common obstetric intervention in the UK, affecting up to 33% of deliveries. IOL aims to achieve a vaginal delivery prior to spontaneous onset of labour to prevent harm from ongoing pregnancy compli…

BACKGROUND: Endometriosis is a debilitating, chronic disease that affects approximately 10% of women of reproductive age worldwide. The most common symptom is chronic pelvic pain, which leads to a reduced quality of life and requires lifelo…

BACKGROUND: Prolonged and repetitive exposure to stressors leads to detrimental effects on female reproductive health; this can consequently increase susceptibility to stress and elevate risk of adverse mental health outcomes. Since October…