PloS one

INTRODUCTION: The human papillomavirus (HPV) is the most common sexually transmitted infection worldwide. The present study aimed to examine the impact of an educational intervention based on the Health Belief Model (HBM) on sexual self-car…

The kinetics and identification of targets of Human Immunodeficiency Virus (HIV) infection within mucosae is a valuable tool for the development of new HIV-prevention strategies. Human tissue explants offer an informative model for studying…

BACKGROUND: Pelvic health conditions significantly impact quality of life and are prevalent in the general population. Urinary and fecal incontinence, pelvic organ prolapse, and pelvic pain are examples of pelvic health conditions. A scopin…

SIGNIFICANCE: Globally, infertility affects 10-15% of couples, with Fallopian Tube Obstruction (FTO) being a principal cause. Current therapeutic options are inadequate, prompting a demand for effective, less invasive treatments with lower …

BACKGROUND: Infertility is a significant public health issue that affects couples worldwide. The impacts of infertility is notably higher in Ethiopia due to various factors, such as cultural stigmas surrounding infertility and inadequate in…

STUDY OBJECTIVE: To report individual early and long-term functional outcomes of 43 women who underwent double circular stapler technique (DCST) for colorectal deep endometriosis (DE). METHODS: This multidisciplinary observational study wa…

ObjectivesAlthough particulate matter (PM) exposure poses significant public health risks, previous research has focused on limited clinical areas. However, emerging evidence and pathological mechanisms of PM suggest that PM may exert broad…

Chromatin remodeling plays an integral part in endometrial homeostasis through its roles in the maintenance of cell identity, epithelial integrity, and prevention of endometrial disease. Chromodomain-helicase-DNA-binding protein 4 (CHD4) is…

BACKGROUND: Endometriosis is a common gynecological disorder among women of reproductive age worldwide. This study aims to examine global patterns of endometriosis disease burden among reproductive-aged women and to evaluate its correlation…

PURPOSE: The global prevalence and trends of gynecological diseases (GDs) among women of childbearing age (WCBA) remain unclear and may be underestimated. This study aims to evaluate the prevalence of GDs at global, regional, and national l…

BackgroundThe injectable glucagon-like peptide-1 (GLP-1) receptor agonist (RA) drugs are commonly used for weight loss among reproductive-aged women but the perception of their impact on fertility is not clear among the public.ObjectivesThe…

BACKGROUND: In Low and Middle-Income Countries (LMICs), 21 million adolescent girls aged between 15 and 19 years become pregnant each year. Adolescent girls in South Asia have the shortest interval to begin maternity, i.e., within 1-2 years…

Endometriosis is a chronic inflammatory disorder characterized by presence of endometrial tissue outside the uterine cavity. Immunohistochemical analysis (IHC) revealed markedly elevated expression of IL6ST in endometrial tissue of patients…

The skeletal muscle is highly susceptible to injury in daily life. Severe skeletal muscle injuries often result in incomplete regeneration, leading to functional impairment. In clinical practice, understanding the extent of skeletal muscle …

INTRODUCTION: Dysmenorrhea and heavy menstrual bleeding are the most common symptoms in adenomyosis, in addition to infertility and chronic pelvic pain. Hysterectomy is a common treatment for adenomyosis symptoms with curative effect on hea…

BACKGROUND: Obesity negatively affects reproduction and in vitro fertilization (IVF) outcomes. However, its effects on lipid metabolism during embryonic development remain unclear. We examined follicular fluid (FF) lipid composition and bod…

Endometriosis is a chronic inflammatory gynaecological condition frequently associated with chronic pelvic pain. Visceral hypersensitivity could be present, like in other chronic pain conditions, causing altered levels of interoception. So …

Uterine fibroids (UFs) are still mysterious lesions, they are influenced by hormonal imbalances and chronic inflammation, with recent emerging evidence suggesting a role for microbiota. While gastrointestinal and vaginal microbiota in UF pa…

BACKGROUND: The optimal endometrial preparation protocol for frozen embryo transfer (FET) remains controversial, with different cycle regimens and luteal phase support strategies across studies yielding conflicting results. This study aimed…

The judicious selection of ovulation inhibitors in ovarian stimulation protocols is crucial for the success of assisted reproductive technology (ART). Herein, we investigate the dose-dependent effects of chlormadinone acetate (CMA) and cetr…

PURPOSE: This study investigates the impact of the Chinese New Year (CNY) holiday on frozen embryo transfer (FET) outcomes in assisted reproductive technology (ART), particularly in vitro fertilization (IVF). Previous research has highlight…

OBJECTIVE: To evaluate the effect of laparoscopic repair of the large niche on short-term and long-term outcomes, i.e., extent of scar healing (increase in scar thickness or residual myometrium (RM) and decrease in niche depth), decrease in…

The aim of the study was to compare the effects of 52 mg Levonorgestrel-releasing intrauterine device (LNG-IUD), which is frequently used in patients with heavy menstrual bleeding, on quality of life according to benign endometrial patholog…