Journal of ovarian research

BACKGROUND: Overweight and obesity can induce an inflammatory milieu in the oocyte microenvironment and are closely associated with reduced assisted reproductive outcomes. OBJECTIVE: How are immune cells, cytokines and lipid profiles alter…

BACKGROUND: Polycystic ovary syndrome (PCOS) is a common endocrine disorder characterized by ovulatory dysfunction, hyperandrogenism, and polycystic ovaries, significantly impacting reproductive health. Obesity, prevalent in 50-80% of PCOS …

OBJECTIVE: To analyze the effect of serum luteinizing hormone (LH) level and increment on the day of endometrial transformation on the outcome of frozen-thawed embryo transfer during the hormone replacement cycle. METHOD: We conducted a ret…

BACKGROUND: Acetyl tributyl citrate (ATBC), a widely used plasticizer, has raised concerns regarding its reproductive toxicity. However, its molecular mechanisms in female infertility and ovarian damage remain poorly characterized. This stu…

BACKGROUND: In vitro fertilization (IVF) has become an integral component of reproductive medicine, providing a pathway to parenthood for infertile and sub-fertile couples. Currently, IVF accounts for approximately 2-5% of all births global…

OBJECTIVE: Mechanism underlying the etiology of polycystic ovary syndrome (PCOS) is still debatable. Present study explores the link between iron-mediated ferroptosis and PCOS. METHODOLOGY: Blood samples were collected from 150 PCOS female…

Long non-coding RNAs (lncRNAs) affect the biological functions of granulosa cells (GCs) through multiple mechanisms, including epigenetic regulation, transcriptional regulation, post-translational modification, and cell signaling. Our previ…

OBJECTIVES: Ovarian cancer can present with malignant ascites at initial diagnosis or disease recurrence. Although indicative of advanced disease, the prognosis of malignant ascites is reported to be favorable for ovarian cancers compared t…

One of the most common side effects of chemotherapy is premature ovarian failure (POF) in women younger than 40. POF is linked to higher levels of gonadotropin hormones, lower levels of estradiol, and increased apoptosis and follicular atre…

BACKGROUND: SUGT1 (Suppressor of the G2 allele of SKP1) and FH (fumarate hydratase) have recently garnered significant attention from the research community. SUGT1 functions as a molecular chaperone, regulating the stability and activity of…

Premature ovarian insufficiency (POI) is a common, heterogeneous disorder that affects up to 3.5% of women under 40 years of age and is defined by oligo/amenorrhoea, hypo-oestrogenism, and markedly elevated gonadotrophin levels. POI substan…

Extracellular vesicles, or exosomes, are produced by every type of cell and contain metabolites, proteins, lipids, and nucleic acids. Their role in health and disease is to influence different aspects of cell biology and to act as intermedi…

BACKGROUD: Ovarian aging can lead to early menopause, infertility, and even premature senility in female patients, seriously impairing the quality of life. Unfortunatly, it is still lack of effective protection strategies against ovarian ag…

Ovarian cancer ranks as the eighth most common malignancy in women globally. Early detection remains a critical challenge for improving ovarian cancer diagnosis and treatment outcomes. Our prior study demonstrated that ARHGAP40 downregulati…

PURPOSE: Polycystic ovary syndrome (PCOS) is currently recognized as a condition that affects several systems in the body, including the reproductive, endocrine, and cardiovascular systems. Prevalent among teenagers and women of reproductiv…

BACKGROUND: Early and accurate triage of adnexal masses remains challenging due to the heterogeneous presentation of ovarian cancer and the fragmented nature of existing diagnostic tools. While several validated algorithms exist-such as NIC…

Ovarian Cancer (OC) is recognized as the most lethal gynecologic malignancy, characterized by numerous genetic mutations that trigger uncontrolled cellular growth and replication. Emerging evidence suggests that non-coding RNAs including mi…

BACKGROUND: Ovarian cancer is the most lethal gynaecological cancer globally. Despite advanced multimodality treatment 5year survival is around 50% and its only 31% in stage IV cancers. There is no clearly defined precursor lesion. The even…

BACKGROUND: Fertility preservation is an important aspect of care for breast cancer patients. This study was designed to compare the ovarian function including ovarian reserve and ovarian stimulation response in breast cancer patients under…

BACKGROUND: Ovarian dysfunction caused by aging restricts female reproductive capacity and causes age-related health problems. Ferroptosis is an important mode of cell death during accelerated aging. Oviductus Ranae (OR), a traditional Chin…

BACKGROUND: Despite epidemiological studies linking phthalates to ovarian cancer, their multi-target molecular mechanisms remain unresolved, hindering biomarker discovery and preventive strategies. This study integrates network toxicology, …

BACKGROUND: Poor ovarian response (POR) is a challenging condition in assisted reproduction technology. Oral contraceptives (OCs) are commonly used to suppress gonadotropin hormone release in POR patients to synchronize the development of a…

BACKGROUND: As women age, their ovarian follicle pool naturally declines. However, female germline stem cells (FGSCs) possess a unique ability to differentiate into oocytes and continuously self-renew, providing an effective means of delayi…

OBJECTIVES: This study aimed to investigate the distribution of molecular signatures in endometriosis- associated ovarian cancer (EAOC) and to develop a prognostic model based on these molecular signatures. METHODS: We retrospectively analy…

OBJECTIVE: To investigate the relationship between follicular fluid pentraxin 3 (PTX-3) levels and ovarian response, embryo quality, and insulin resistance (IR) in patients with polycystic ovary syndrome (PCOS) undergoing IVF/ICSI. METHODS…