Journal of ovarian research

BACKGROUND: Mosaic embryos have been proven to be capable of resulting in live births and have become an option for embryo transfer under certain circumstances. Recent guidelines suggested that embryo morphological scoring should be taken i…

PURPOSE: To conduct a comparative metabolomic analysis of follicular fluid (FF) from patients undergoing in vitro fertilization (IVF) cycles under GnRH agonist versus antagonist protocols, aiming to identify protocol-specific metabolic sign…

OBJECTIVE: To investigate the determinants affecting live birth outcomes in fresh embryo transfer among polycystic ovary syndrome (PCOS) patients using various machine learning (ML) algorithms and to construct predictive models, offering no…

OBJECTIVE: To evaluate the relationship between serum Anti-Mullerian hormone (AMH) levels, antral follicle count (AFC), and histologically quantified primordial follicle numbers in premenopausal women, in order to validate the clinical accu…

Polycystic ovary syndrome (PCOS) is a common reproductive disorder characterized by hyperandrogenism, ovulatory dysfunction, and polycystic ovaries. The quality of oocytes in PCOS patients remains poor, leading to poor pregnancy outcomes. T…

BACKGROUND: Patients with diminished ovarian reserve (DOR) typically have fewer retrieved oocytes and lower pregnancy rates than normal responders. Therefore, maximizing oocyte yield is particularly important to improve their reproductive o…

ObjectivesTo develop a multidimensional clinical indicator-based prediction model for identifying high-risk patients with fertilization failure conventional in vitro fertilization (c-IVF) cycles, thereby optimizing therapeutic decision-maki…

BACKGROUND: Polycystic ovary syndrome (PCOS) is a common endocrine disorder affecting women of reproductive age. It is characterized by symptoms such as hyperandrogenemia, oligo or anovulation and polycystic ovarian, significantly impacting…

BACKGROUND: Total fertilization failure (TFF) or near TFF may lead to cycle cancellation, which is a highly frustrating experience for patients, especially those who have undergone multiple attempts. Early rescue intracytoplasmic sperm inje…

BACKGROUND: Human reproduction is intricately linked to systemic metabolic regulation, with disturbances in glucose metabolism adversely affecting fertility outcomes. Beyond their classical role in lipid digestion, bile acids (BAs), cholest…

BACKGROUND: The live birth rates (LBRs) do not rise after a certain number of oocytes are collected in fresh IVF cycles. Although the detrimental effect of high ovarian response on the endometrium has been recognised, the effect of high ooc…

Ovarian cancer remains one of the most lethal gynecologic malignancies, often marked by late-stage diagnosis and resistance to conventional therapies. Poly (ADP-ribose) polymerase (PARP) inhibitors have significantly advanced treatment, par…

OBJECTIVE: To evaluate the pregnancy and perinatal outcomes of different phenotypes of polycystic ovary syndrome (PCOS) patients during the frozen embryo transfer (FET) cycles. Additionally, to analyze the T cell balance in the endometrium …

BACKGROUND: Oxidative stress (OS) is a significant challenge in the in vitro embryo culture of patients of advanced age. The Erzhi Tiangui (EZTG) formula has been shown to alleviate OS-induced apoptosis in granulosa cells (GCs) of patients …

BACKGROUND: Polycystic ovary syndrome (PCOS) is an endocrine disease associated with reproductive and metabolic abnormalities. The aim of this study was to elucidate the effects of Schisandra rubriflora (S. rubriflora) on PCOS and its relat…

BACKGROUND: The principal indicators adopted for the assessment of follicular quality are still two-dimensional ultrasound(2D-US) imaging parameters, but these do not reflect the three-dimensional morphology of follicles. We herein aimed to…

Infertility is a significant global health issue affecting millions of couples, with noncoding RNAs (ncRNAs) emerging as pivotal regulators in reproductive biology. This review explores the roles of various ncRNAs, including microRNAs (miRN…

The gut microbiota is a complex community of microorganisms that inhabit the human gastrointestinal tract, helping to maintain the ecological balance of the body's internal and external environments. Disruptions in the composition and diver…

Ovarian cancer, an aggressive gynecological tumor, is primarily driven by persistent inflammation and resistance to conventional treatments. High-risk human papillomavirus (HR-HPV) has been identified as a potential contributing factor to d…

BACKGROUND: Approximately 100,000 human endogenous retroviruses (HERV) are integrated into the human genome. Most HERVs are not expressed; however, transcription within the family HERV-K, a class II beta-retrovirus, occurs in specific cance…

BACKGROUND: Polycystic ovary syndrome (PCOS) is a common endocrine disorder with significant impacts on women’s reproductive health. Interleukin (IL)-2 receptor subunit gamma (IL2RG), a common receptor for IL-2, IL-4, IL-7, IL-9, IL-15 and …

BACKGROUND: Overweight and obesity can induce an inflammatory milieu in the oocyte microenvironment and are closely associated with reduced assisted reproductive outcomes. OBJECTIVE: How are immune cells, cytokines and lipid profiles alter…

BACKGROUND: Polycystic ovary syndrome (PCOS) is a common endocrine disorder characterized by ovulatory dysfunction, hyperandrogenism, and polycystic ovaries, significantly impacting reproductive health. Obesity, prevalent in 50-80% of PCOS …

OBJECTIVE: To analyze the effect of serum luteinizing hormone (LH) level and increment on the day of endometrial transformation on the outcome of frozen-thawed embryo transfer during the hormone replacement cycle. METHOD: We conducted a ret…

BACKGROUND: Acetyl tributyl citrate (ATBC), a widely used plasticizer, has raised concerns regarding its reproductive toxicity. However, its molecular mechanisms in female infertility and ovarian damage remain poorly characterized. This stu…