Human Reproduction

STUDY QUESTION: Can predictors of low and high ovarian responses be identified in patients undergoing controlled ovarian stimulation (COS) in a GnRH antagonist protocol? SUMMARY ANSWER: Common prognostic factors for high and low ovarian re…

STUDY QUESTION: Are protein oxidative stress markers [thiols, advanced oxidation protein products (AOPP), protein carbonyls and nitrates/nitrites] in perioperative peritoneal fluid higher in women with histologically proven endometriosis wh…

STUDY QUESTION: How does endothelial function change in women with endometriosis after surgical treatment? SUMMARY ANSWER: Surgical treatment of endometriosis leads to endothelial function improvement, resulting in reduction of cardiovascu…

Antral follicle count might

STUDY QUESTION: What reproductive choices do women make after they have cryopreserved oocytes for medical reasons? SUMMARY ANSWER: Women who had cryopreserved oocytes for medical reasons and tried to become pregnant, either attempted natur…

STUDY QUESTION: Is endometrial thickness measured prior to embryo transfer associated with placenta praevia? SUMMARY ANSWER: Following IVF, the risk of placenta praevia is increased 4-fold in women with an endometrial thickness of >12 mm c…

Endometrial scratching or injury was first suggested a decade ago as a simple intervention to improve endometrial receptivity in patients undergoing ART. More than a decade later, based on weak evidence some doctors have adopted this strate…

STUDY QUESTION: Is there a relationship between severe teenage acne and endometriosis? SUMMARY ANSWER: Endometriosis is positively associated with severe teenage acne. WHAT IS KNOWN ALREADY: No studies have specifically explored a possibl…

Over the last several years, with improvements in laparoscopic surgical techniques, specialized surgical teams have successfully been able to safely excise deep endometriosis lesions that infiltrate into and may compromise the bladder, bowe…

STUDY QUESTION: Does surgical treatment of endometriomas impact on the ovarian reserve as evaluated with antral follicle count (AFC)? SUMMARY ANSWER: This meta-analysis of published data shows that surgery for endometrioma does not signifi…

STUDY QUESTION: In the use of 'tenderness-guided' transvaginal ultrasound, is the diagnostic accuracy of three-dimensional (3D) ultrasonography better than two-dimensional (2D) ultrasonography in the identification of deep endometriosis? S…

STUDY QUESTION: Is adenomyosis associated with IVF/ICSI outcome in terms of clinical pregnancy rate? SUMMARY ANSWER: In a meta-analysis of published data, women with adenomyosis had a 28% reduction in the likelihood of clinical pregnancy a…

STUDY QUESTION: Is there any combined effect between inflammation and stress reaction on Toll-like receptor 4 (TLR4)-mediated growth of endometriotic cells? SUMMARY ANSWER: A combined effect of local inflammation and stress reaction in the…

STUDY QUESTION: Is pigment epithelium-derived factor (PEDF) expressed in the rodent endometrium and can it be utilized to treat endometriosis without negatively affecting reproductive parameters? SUMMARY ANSWER: PEDF is dynamically express…

STUDY QUESTION: Does the novel progesterone receptor (PR) modulator BAY 1002670, based on its preclinical pharmacological profile, offer a potential novel treatment option for uterine fibroids? SUMMARY ANSWER: The newly synthesized BAY1002…

STUDY QUESTION: Is there a relationship between body mass index (BMI), body shape and endometriosis? SUMMARY ANSWER: Endometriosis is inversely associated with early adult BMI and may correlate with a peripheral body fat distribution. WHA…

STUDY QUESTION: Can we use chemokines as biomarkers to diagnose patients with endometriosis in clinical practice? SUMMARY ANSWER: Some chemokines, especially CXCL8 (IL-8), CCL-2 (MCP-1) and CCL5 (RANTES), have the potential to work as biom…

STUDY QUESTION: Is endometriosis associated with changes in CD4⁺ CD25⁺ FOXP3⁺ regulatory T cells (Treg cells)? SUMMARY ANSWER: Endometriosis is associated with disturbed compartmentalization of CD25(high) FOXP3⁺ Treg cells. WHAT IS KNOWN …

STUDY QUESTION: How do fully-comprehensive patient-centred descriptions of the symptoms of endometriosis compare with the physicians' description of the symptoms? SUMMARY ANSWER: The description of the painful symptoms due to endometriosis…