BMJ open

BMJ Open · ISSN (e) 2044-6055 · 290 papers in corpus
other 2026
doi:10.1136/bmjopen-2025-112126 ·PMID:42191199

INTRODUCTION: Adnexal surgery is one of the most common surgeries performed in women. Minimally invasive methods are on the rise globally as they have been shown to decrease surgical morbidity compared with abdominal surgery. Adnexal surger…

observational 2026
doi:10.1136/bmjopen-2025-115665 ·PMID:42624608

OBJECTIVES: To assess the impact of non-communicable diseases (NCDs) by number and pattern on productivity loss costs (PLCs) and health-related quality of life (HRQoL) in a large working-age population in Japan. DESIGN: Cross-sectional ana…

other 2026
doi:10.1136/bmjopen-2025-112291 ·PMID:42049313

INTRODUCTION: The Ablative Technique Options for Preserving fertility in Endometrioma study is a prospective, monocentric clinical study that combines a randomised controlled trial comparing cystectomy and plasma vapourisation for endometri…

other 2026
doi:10.1136/bmjopen-2025-111265 ·PMID:41605576

INTRODUCTION: Unexplained infertility affects about 30% of couples seeking help for infertility, yet the optimal ovulation induction strategy remains largely unclear. Letrozole, clomiphene citrate and gonadotropins are widely used, alone or…

rct 2026
doi:10.1136/bmjopen-2024-090247 ·PMID:41840742

OBJECTIVE: To evaluate the cost-effectiveness of the levonorgestrel intrauterine system (LNG-IUS) compared with hysteroscopic niche resection (HNR) for women with niche-related postmenstrual spotting. DESIGN: Economic evaluation from a hea…

qualitative 2026
doi:10.1136/bmjopen-2025-113914 ·PMID:42392633

BACKGROUND: Menstrual health (MH) is vital to women's overall health and well-being. Yet many women, especially in resource-limited settings, face challenges due to insufficient resources and support. Most MH research has focused on school-…

other 2026
doi:10.1136/bmjopen-2025-109888 ·PMID:41734921

INTRODUCTION: Endometriosis is a chronic, oestrogen-dependent condition with a wide range of symptoms and comorbidities that significantly affect physical, emotional and psychological well-being, as well as quality of life. Women with endom…

observational 2026
doi:10.1136/bmjopen-2025-115285 ·PMID:42567635

ObjectivesThe relationship between clomiphene citrate (CC) dosing regimens and adverse reproductive outcomes has not been fully elucidated, both with and without use of in vitro fertilisation (IVF). We aimed to study the association between…

rct 2026
doi:10.1136/bmjopen-2026-116964 ·PMID:42191188

INTRODUCTION: Treatment for women with endometriosis is only partially or temporarily effective. Moreover, medical hormonal treatment is associated with debilitating side effects and interferes with fertility, while surgery has a relatively…

other 2026
doi:10.1136/bmjopen-2025-114124 ·PMID:42624581

INTRODUCTION: Endometriosis is associated with reduced pregnancy and live birth rates in patients attempting both spontaneous and assisted conception. At present, it is unclear whether prepregnancy surgery for moderate or severe endometrios…

other 2026
doi:10.1136/bmjopen-2025-111928 ·PMID:41881534

INTRODUCTION: Endometriosis is a chronic, inflammatory and oestrogen-dependent disease frequently causing infertility. Assisted reproductive technologies (ART) are often required to achieve pregnancy, especially in women with advanced endom…

other 2026
doi:10.1136/bmjopen-2025-111270 ·PMID:41922060

OBJECTIVES: The research explored how individuals experience chronic pain within their everyday social contexts over a 12-month period. The study focused on the interplay between pain and social worlds, through analysis of experiences of so…

qualitative 2026
doi:10.1136/bmjopen-2026-121990 ·PMID:42692504

BACKGROUND: Endometriosis affects approximately one in seven women in Australia and is associated with substantial physical, psychological and social impacts. Informational support is critical for enabling informed decision-making and foste…

observational 2026
doi:10.1136/bmjopen-2025-101527 ·PMID:42398988

INTRODUCTION: Innovative clinical trials, including adaptive and Bayesian designs, can improve efficiency and prioritise patient-centric approaches. Despite their recognised advantages, the global adoption of innovative clinical trial desig…

observational 2026
doi:10.1136/bmjopen-2025-112480 ·PMID:42567631

OBJECTIVES: This study estimates the cost of managing infertility, including intrauterine insemination (IUI) from health system perspective in India. DESIGN: This was a retrospective cross-sectional microcosting study using mixed approach.…

2026
other 2026
doi:10.1136/bmjopen-2026-123353 ·PMID:42731840

INTRODUCTION: Chronic pain is a leading public health problem, impacting over 1.5 billion people worldwide. Standard-of-care includes pharmaceutical medication, surgery and physical therapy, yet many patients experience continued symptoms. …

observational 2026
doi:10.1136/bmjopen-2025-103421 ·PMID:41916631

OBJECTIVES: To investigate the knowledge, attitudes and practices (KAP) regarding mammary gland hyperplasia (MGH) in adult women from Shandong province, China. DESIGN: A cross-sectional study. SETTING: This study was conducted in Shandong…

qualitative 2026
doi:10.1136/bmjopen-2025-110262 ·PMID:42481196

OBJECTIVES: The focus of the present study is to highlight and understand the effect of hysterectomy on physical, psychological, social and marital status among women aged under 40 years of age, in the cultural context of Pakistan DESIGN: T…

observational 2026
doi:10.1136/bmjopen-2024-097959 ·PMID:42082250

OBJECTIVES: There is evidence that treatment expectations predict treatment outcomes in pain management and other clinical conditions. However, translating these insights into clinical practice remains challenging: it is difficult to measur…

observational 2026
doi:10.1136/bmjopen-2026-119165 ·PMID:42810796

OBJECTIVES: To characterise the symptom, comorbidity and diagnostic journey of adult and older adolescent patients with postural orthostatic tachycardia syndrome (POTS). DESIGN: Cross-sectional observational cohort study. SETTING: Partici…

other 2026
doi:10.1136/bmjopen-2026-118954 ·PMID:42552011

INTRODUCTION: Chronic non-specific knee pain represents a prevalent and disabling musculoskeletal condition that often lacks a clearly identifiable structural cause and evidence-based management strategies. Photobiomodulation therapy combin…

other 2026
doi:10.1136/bmjopen-2026-123210 ·PMID:42680495

INTRODUCTION: Premenstrual symptoms occur on a continuum from mild experiences to clinically significant, menstrual cycle-related mood disorders, including premenstrual dysphoric disorder (PMDD). Stress has been implicated as a key pathophy…

observational 2026
doi:10.1136/bmjopen-2026-117740 ·PMID:42457424

OBJECTIVES: This study examines heterogeneity in women's use of reproductive healthcare services before and after receiving an infertility diagnosis and its association with pregnancy identified without recorded loss within one year followi…

observational 2026
doi:10.1136/bmjopen-2026-116361 ·PMID:42366011

OBJECTIVE: Women with premenstrual disorder (PMD) display heightened sensitivity to hormonal changes and may be at risk for psychiatric disorders during other hormonally dynamic periods such as pregnancy and postpartum. While PMD has been l…