Frontiers in endocrinology

BACKGROUND: Oxidative balance within follicular fluid (FF) plays an important role in oocyte competence and female fertility. However, most previous studies have focused on isolated oxidative biomarkers rather than on the coordinated organi…

BACKGROUND: First-line treatment with non-steroidal anti-inflammatory drugs like ibuprofen for primary dysmenorrhea is effective for short-term pain relief but is often associated with a high recurrence of pain upon discontinuation. Traditi…

Primary aldosteronism (PA) is associated with a substantially higher cardiovascular risk than essential hypertension, a disparity that cannot be fully explained by blood pressure elevation alone. Clinical studies consistently demonstrate th…

INTRODUCTION: Each month, the endometrium is shed, regenerated, and transformed in response to changing hormone levels. These processes occur in a tightly regulated manner, and irregularities are linked with reproductive health conditions s…

BACKGROUND: Endometriosis, PCOS, adenomyosis, and dysmenorrhea are major illnesses. Hormonal as well as non-hormonal treatments were evaluated for COCs, progestins, GnRH analogues, LNG-IUS, relugolix, and adjunctive therapies. These treatme…

BACKGROUND: Diminished ovarian reserve (DOR) has emerged as a significant reproductive challenge and a broader societal concern. Most previous studies have focused on ovarian reserve markers, while limited research has examined DOR as a pri…

BACKGROUND: Diminished ovarian reserve (DOR) is a major cause of infertility and remains a core challenge in reproductive medicine. Although previous studies have suggested that acupuncture may improve reproductive outcomes in infertile wom…

OBJECTIVE: To evaluate the impact of day 4 double embryo transfer (DET) with a fully compacted morula (FCM) and a partially compacted morula (PCM) versus day 4 single embryo transfer (SET) with an FCM on clinical and neonatal outcomes in fr…

BACKGROUND: The selection of a frozen-thawed embryo transfer (FET) strategy requires balancing the potential for improved clinical pregnancy and live birth outcomes against the risk of multiple pregnancy. However, comprehensive evaluations …

OBJECTIVE: Current studies on adverse pregnancy outcomes in polycystic ovary syndrome (PCOS) have primarily focused on metabolic and endocrine abnormalities, whereas systematic investigations addressing live birth outcomes and coagulation d…

BACKGROUND: Polycystic ovary syndrome (PCOS) is a heterogeneous endocrine disorder associated with both reproductive and metabolic dysregulation. While anti-Müllerian hormone (AMH) and the triglyceride-glucose (TyG) index have been independ…

BACKGROUND: Polycystic Ovary Syndrome (PCOS) is a common endocrine disorder characterized by obesity, insulin resistance, and cardiometabolic risks. Lifestyle intervention is first-line therapy, but drug therapy is often necessary. Common t…

OBJECTIVE: To compare the clinical effectiveness of combined oral contraceptive pills (levonorgestrel-containing COC) and dienogest in the management of endometriosis-associated chronic pelvic pain and related symptoms. METHODS: This prosp…

BACKGROUND: To compare the efficacy of modified gonadotropin-releasing hormone (GnRH) antagonist protocols combining clomiphene citrate (CC) or letrozole (LE) versus a conventional antagonist protocol in patients with normal ovarian reserve…

OBJECTIVE: The aim of this retrospective cohort study was to evaluate the clinical and neonatal outcomes between day 4 and day 5 embryo transfer across different fertilization methods. METHODS: This retrospective cohort study was conducted…

OBJECTIVE: To compare the euploidy rate between ovulation suppression protocols using PPOS and GnRH-ant, and to evaluate possible variables associated with euploidy rate such as age, BMI, infertility duration, treatment-related factors, and…

OBJECTIVE: To compare the clinical efficacy of letrozole-induced ovulation cycles, natural cycles, and Hormonal Replacement Therapy cycle in frozen embryo transfer (FET), and to investigate the effects of different endometrial preparation p…

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[This corrects the article DOI: 10.3389/fendo.2025.1687765.].

[This corrects the article DOI: 10.3389/fendo.2025.1602814.].

BACKGROUND: Idiopathic male infertility (IMI) accounts for 30%-40% of male infertility cases, yet the molecular networks associated with seminal plasma dysfunction and non-invasive biomarkers remain largely unclear. This study aimed to prel…

OBJECTIVE: To compare cumulative live birth rates (CLBR) between preimplantation genetic testing for aneuploidy (PGT-A) and conventional IVF/ICSI in women with unexplained recurrent pregnancy loss (uRPL) using intention-to-treat (ITT) and p…

BACKGROUND: Technological advances have revolutionised the microbiome research in the field of human reproduction, identifying the microbiome as important regulator of reproductive health and functions, where microbes are now linked to sper…

OBJECTIVE: This study aimed to evaluate factors associated with the clinical pregnancy rate in women with diminished ovarian reserve (DOR) undergoing repeated assisted reproductive technology (ART) cycles. METHODS: A retrospective analysis…