Frontiers in endocrinology

BACKGROUND: Predicting clinical pregnancy following intrauterine insemination (IUI) remains challenging because of the complex interplay of multiple biological and treatment-related factors. Machine learning approaches may improve predictiv…

OBJECTIVE: This study aimed to explore the feasibility of developing and internal validating machine learning (ML) models for post-retrieval ovarian hyperstimulation syndrome (OHSS) risk stratification in patients undergoing assisted reprod…

BACKGROUND: In clinical practice, the management of luteinizing hormone (LH) levels during controlled ovarian hyperstimulation (COH) with gonadotropin releasing hormone antagonist (GnRH-ant) protocols presents a significant challenge that c…

BACKGROUND: Effective individualized tools to predict cumulative live birth rates are lacking for patients with ovarian endometriomas undergoing In Vitro Fertilization or Intracytoplasmic Sperm Injection after ultrasound-guided ethanol scle…

BACKGROUND: Current guidelines recommend laparoscopic cystectomy for ovarian endometrioma (OMA) ≥4 cm before fertility treatment, yet cystectomy inevitably damages ovarian reserve. While recent large-scale studies have confirmed that cystec…

PURPOSE: To investigate whether controlled ovarian stimulation (COS), as part of assisted reproductive technology (ART), accelerates the progression of BI-RADS categories. METHODS: This was a single-center, retrospective, propensity score …

BACKGROUND: Adenomyosis is a heterogeneous uterine disorder characterized by the presence of endometrial tissue within the myometrium. Autophagy, a key homeostatic process involved in tissue remodeling and stress adaptation, has been incons…

BACKGROUND: First implantation failure (FIF) remains a significant challenge in in vitro fertilization/intracytoplasmic sperm injection-embryo transfer (IVF/ICSI-ET), and a considerable proportion of affected women subsequently progress to …

Understanding the molecular heterogeneity of endometriosis is essen7al for moving toward precision medicine. Situmorang et al. highlighted that the disease's three main phenotypessuperficial peritoneal endometriosis (SUP), ovarian endometri…

INTRODUCTION: Acupuncture has been explored as a potential intervention for POR; however, high-quality evidence is limited. This multicenter randomized trial evaluated the effect of acupuncture on the number of oocytes retrieved following c…

INTRODUCTION: Diminished ovarian reserve (DOR) is known to reduce the likelihood of achieving pregnancy or live births in women undergoing in vitro fertilization and embryo transfer (IVF-ET). Acupuncture maybe effective for DOR, but current…

BACKGROUND: Pericentric inversion of chromosome 9 [inv (9)] is a common chromosomal polymorphism found in approximately 1-2% of the population. While inv(9) has been generally considered a benign variant, its potential effects on reproducti…

OBJECTIVE: This retrospective cohort study aimed to evaluate whether a goal-directed weight loss intervention prior to assisted reproductive technology (ART) improves live birth rates compared with immediate in vitro fertilization (IVF) wit…

BACKGROUND: Primary dysmenorrhea (PD) is defined as pain occurring with menses in the absence of pelvic pathology. Traditional Chinese Medicine offers various therapeutic approaches for PD management. Dysmenorrhea Patch, an acupoint applica…

OBJECTIVES: This study evaluated the efficacy of individualized follitropin delta dosing in patients with potential low response, defined by anti-Müllerian hormone (AMH) level <9 pmol/L, undergoing ovarian stimulation for assisted reproduct…

BACKGROUND: Insulin resistance has been linked to adverse reproductive and pregnancy outcomes. The triglyceride glucose-body mass index (TyG-BMI) serves as a simple and cost-effective surrogate marker of insulin resistance. This study aimed…

BACKGROUND: The relationship between endometrial thickness and adverse pregnancy outcomes has garnered significant attention from researchers. The aim of this study was to investigates whether endometrial thickness (EMT) is a risk factor fo…

Endometriosis is a common, chronic inflammatory condition characterized by the presence of endometrium-like tissue outside of the uterus that can impact fertility through multiple mechanisms. In this review, the diagnosis, classification, s…

OBJECTIVE: To systematically evaluate the evidence on the contraceptive efficacy, cycle control, safety, and selected noncontraceptive effects of estetrol 15 mg/drospirenone 3 mg (E4/DRSP) and to assess certainty of evidence by outcome usin…

IMPORTANCE: Female infertility affects approximately one in six couples worldwide and disproportionately impacts women aged 30-42 years, yet evidence on which interventions improve clinically meaningful outcomes (live birth and safety) is h…

INTRODUCTION: Anogenital distance (AGD) and penile length (PL) are considered as surrogate biomarkers of fetal androgen action and are used to study the impact of prenatal exposure to endocrine disrupting chemicals. Data for newborn sex-spe…

BACKGROUNDS: Abnormal cleavage (ABNCL) in early human embryos is a frequent phenomenon associated with impaired developmental competence and reduced reproductive potential. However, the clinical determinants of ABNCL and its subtypes remain…

BACKGROUND: Polycystic ovary syndrome (PCOS) is characterized by altered follicular development and metabolic dysfunction, frequently exacerbated by obesity. The follicular fluid (FF) microenvironment plays a critical role in supporting ooc…

INTRODUCTION: PCOS is the most common disorder encompassing reproductive, metabolic, and endocrine abnormalities, and has an increased risk of adverse pregnancy and neonatal complications, such as miscarriage, gestational diabetes mellitus,…