Journal of pain research

PurposeVaginal delivery is the most common mode of childbirth, and women often experience severe uterine contraction pain (UCP) for several days postpartum, which can significantly impair postpartum recovery. Acupuncture has proven efficacy…

BACKGROUND: Endometriosis is a chronic gynecological disorder characterized by pain and impaired quality of life (QoL). While pharmacological and surgical options exist, their limitations necessitate complementary strategies. The comparativ…

ObjectiveTo identify core acupoint prescription patterns for primary dysmenorrhea (PD) using data mining and to generate hypothesis-level mechanistic insight through network-based analysis.MethodsNine Chinese and English databases were sear…

BackgroundPrimary dysmenorrhea is fundamentally driven by uterine ischemia resulting from excessive vascular resistance. While acupuncture is theorized to improve perfusion, high-quality evidence controlling for pharmacological confounders …

ObjectiveTo identify the risk factors for severe primary dysmenorrhea in adolescent girls and provide evidence for clinical prevention and intervention.MethodsThis retrospective study enrolled adolescent girls with primary dysmenorrhea from…

PURPOSE: Adenomyosis, a common gynecologic condition of the uterus, affects women with diverse symptoms including pain. Traditionally evaluated pathologically, advanced imaging modality has led to more diagnoses including asymptomatic women…

PURPOSE: Body perception disturbances, such as distorted perception of limb size, are well documented in specific pain conditions like complex regional pain syndrome but remain underexplored in chronic pain more broadly. This qualitative st…

BACKGROUND: Endometriosis (EMS) is characterized by pain symptoms that seriously affect patients' quality of life. Gut microbiome-related metabolites (GMRM) play an important role in the process of EMS. However, the role of GMRM in endometr…

Migraine is a highly prevalent and disabling neurological disorder with multiple hypotheses regarding its pathogenesis. G protein-coupled receptor 30 (GPR30), a member of the G protein-coupled receptor family, was once considered a membrane…

ObjectiveThis study aimed to evaluate the impact of succinylcholine on the incidence of postoperative sore throat (POST) in patients undergoing hysteroscopy under laryngeal mask airway (LMA)-assisted general anesthesia.DesignA prospective, …

BackgroundThis network meta-analysis (NMA) aimed to explore the impact of Non-pharmacological therapies (NPT) on alleviating primary dysmenorrhea (PD) symptoms and assess the effectiveness differences among various NPT.MethodsWe searched se…

Background and objectivePrimary dysmenorrhea carries substantial medical, social, and economic burdens, leading many patients to seek low-risk complementary and alternative therapies, such as acupuncture. Myofascial trigger point dry needli…

BackgroundAcupuncture and moxibustion, as traditional therapies in Chinese medicine, are widely recognized for their therapeutic effects, particularly in pain relief. Nevertheless, the exact mechanisms underlying their analgesic effects rem…

OBJECTIVE: To develop and validate a nomogram prediction model for chronic pain after hysterectomy for uterine fibroids. METHODS: A retrospective study was conducted on 315 patients who visited our hospital from January 2022 to July 2024. …

ObjectivePrimary dysmenorrhea (PD) is a recurrent disease. The current treatments for PD often fail to provide long-lasting effects, underscoring the necessity for new treatment options that can offer durable benefits. Previous studies have…

Chronic pain is a major cause of suffering. This interferes with daily functioning and is often accompanied by distress. However, current therapeutic strategies for chronic pain are unsatisfactory because of poor understanding of its mechan…

BackgroundBehaviour suggestive of addiction in some patients on long-term oral liquid morphine (OLM) caused concern amongst the Hospice Africa Uganda clinical team and prompted the survey. This survey aimed to identify serious adverse drug …

Pain management remains a critical priority in clinical practice. Meanwhile, traditional analgesics, including non-opioid and opioid medications, often pose substantial risks, including adverse effects and potential for addiction. The recen…

IntroductionIncreasing evidence has indicated that prescription opioid use is associated with poor prognosis in patients with fibromyalgia. However, it remains unknown whether there are causal associations between prescription opioid and fi…

Background: Female chronic pelvic pain disorders (CPPDs) affect 1 in 7 women worldwide and are characterized by psychosocial comorbidities, including a reduced quality of life and 2– 10-fold increased risk of depression and anxiety. Despite…

BackgroundAccumulating studies have revealed altered brain function and structure in regions linked to sensory, pain and emotion in individuals with primary dysmenorrhea (PD). However, the changes in the topological properties of the brain'…