Journal of pain research

ObjectivePrimary dysmenorrhea (PD) is a recurrent disease. The current treatments for PD often fail to provide long-lasting effects, underscoring the necessity for new treatment options that can offer durable benefits. Previous studies have…

Chronic pain is a major cause of suffering. This interferes with daily functioning and is often accompanied by distress. However, current therapeutic strategies for chronic pain are unsatisfactory because of poor understanding of its mechan…

BackgroundBehaviour suggestive of addiction in some patients on long-term oral liquid morphine (OLM) caused concern amongst the Hospice Africa Uganda clinical team and prompted the survey. This survey aimed to identify serious adverse drug …

Pain management remains a critical priority in clinical practice. Meanwhile, traditional analgesics, including non-opioid and opioid medications, often pose substantial risks, including adverse effects and potential for addiction. The recen…

IntroductionIncreasing evidence has indicated that prescription opioid use is associated with poor prognosis in patients with fibromyalgia. However, it remains unknown whether there are causal associations between prescription opioid and fi…

Background: Female chronic pelvic pain disorders (CPPDs) affect 1 in 7 women worldwide and are characterized by psychosocial comorbidities, including a reduced quality of life and 2– 10-fold increased risk of depression and anxiety. Despite…

BackgroundAccumulating studies have revealed altered brain function and structure in regions linked to sensory, pain and emotion in individuals with primary dysmenorrhea (PD). However, the changes in the topological properties of the brain'…

BACKGROUND: Acupuncture and related therapies are effective and safe ways to relieve the pain, and improve the health and quality of life in women with endometriosis-related pain. However, it is still unclear which treatment is the most eff…

PurposeWe aimed to assess uterine and arcuate artery Doppler indices in patients with mild primary dysmenorrhea.Patients and methodsA total of 55 patients were included, consisting of women without dysmenorrhea (n=26, group A) and women wit…

OBJECTIVE: This study aimed to explore the distribution of nerve fibers in abdominal wall endometriosis (AWE) and discern their association with pain. METHODS: A retrospective case-control study was conducted. The cases comprised 30 patien…

Dysmenorrhea is the most common pathology women of childbearing age face. It is defined as painful uterine cramping associated with menstruation. Primary dysmenorrhea occurs in the absence of an organic cause, whereas secondary dysmenorrhea…

PURPOSE: The aim of this study was to describe the effectiveness of an electronic health record best practice alert (BPA) in decreasing gynecologic post-discharge opioid prescribing following benign minimally invasive hysterectomy. PATIENT…

BackgroundStress can have paradoxical effects on pain, namely hyperalgesia and hypoalgesia. Four situational characteristics activate the hypothalamic-pituitary-adrenal axis, leading to a physiological stress response: lacking Sense of cont…

ObjectiveThis research aimed to assess the effectiveness of manual therapy in alleviating pain among women undergoing primary dysmenorrhea (PD).MethodsAll randomized controlled trials (RCTs) regarding manual therapy for PD were searched fro…

PurposePain is an understudied physiological effect of spaceflight. Changes in inflammatory and tissue degradation markers are often associated with painful conditions. Our aim was to evaluate the changes in markers associated with tissue d…

PurposeIt is asserted that primary dysmenorrhea/menstrual cramps only occur in ovulatory menstrual cycles. Our first objective was to present detailed menstrual cramps information in normally ovulatory versus anovulatory cycles from a singl…

IntroductionResearch suggests that sacroiliac joint (SIJ) dysfunction is responsible for 15% to 30% of reported low back pain cases. Recently, there has been an increasing interest in SIJ fusion using minimally invasive surgery (MIS) due to…

AIM: Visceral pain, characterized by pain that is diffuse and challenging to localize, occurs frequently and is difficult to treat. In cases where the pain becomes intractable despite optimal medical management, it can affect patients' Qual…

PurposeUrologic chronic pelvic pain syndrome has attracted a lot of attention in the new century, and an increasing number of relevant studies have been published. Therefore, we performed a bibliometric analysis of these publications, hopin…

PurposeSleep impairment is associated with many chronic pain disorders. While there is an association between chronic pain and sleep disturbances, little is known about the influence of pharmacotherapy for chronic pain conditions, particula…

PurposeDysmenorrhea is the most common gynecological condition among women of childbearing age and remains a challenging public health issue. This study aimed to visualize profiles and hotspots in dysmenorrhea research through a bibliometri…

PurposeThe objective of this study is to evaluate the immediate and time-dependent effects of AA in treating PD and assess its safety.Methods/designThis study is a randomized, single-blinded, controlled trial that will enroll 92 patients in…

Dysmenorrhea, classified as primary dysmenorrhea and secondary dysmenorrhea, is a common gynecological symptom that seriously affects female daily life. At present, studies on dysmenorrhea are numerous and complex. To better reflect the tre…