International journal of women's health

PURPOSE: Living habits affect female endocrine function and fertility, along with aging and other life factors. Because of this, female reproductive health can be promoted through living habit adjustment. METHODS: We used two-sample Mendel…

BACKGROUND: The atypical hemolytic uremic syndrome (aHUS) presents diagnostic and therapeutic challenges due to overlapping features with other conditions like Preeclampsia/HELLP syndrome and thrombotic thrombocytopenic purpura (TTP). Pregn…

BACKGROUND: Previous studies have suggested that aging may influence reproductive functions of female. Nonetheless, the causal relationship between aging and endometriosis has yet to be completely understood. OBJECTIVE: This study aims to …

INTRODUCTION: Heavy menstrual bleeding (menorrhagia) affects 10 million reproductive-age women. Stress is a mechanism for menstrual disorders, and during the COVID-19 pandemic, women reported worsening premenstrual and menstrual symptoms. W…

PURPOSE: This mendelian randomization (MR) study aimed to investigate whether endometriosis, overall and stratified by stage (I/II vs III/IV), confers causal effects on adverse pregnancy and perinatal outcomes. METHODS: Exposure data came …

INTRODUCTION: Endometriosis is a chronic gynecological disorder that significantly impacts women of reproductive age. Recent evidence suggests a bidirectional link between endometriosis and brain functional networks, though the causal mecha…

PURPOSE: Although observational studies suggest a link between socioeconomic status (SES) and hormone-related gynecologic diseases, the causal direction and mediating mechanisms remain unclear. This study aims to explore the causal relation…

BACKGROUND AND AIM: Pelvic inflammatory disease (PID), a chronic infection of the female upper genital tract, is a leading cause of morbidity in reproductive-aged women, often resulting in chronic pelvic pain, tubal infertility, and ectopic…

OBJECTIVE: To investigate the effects of Modified Hupo San on reproductive hormone levels and microcirculation in patients with menstrual disorders of cold congelation and blood stasis pattern. METHODS: A total of 102 patients from the gyn…

OBJECTIVE: This study conducted a retrospective matched analysis to explore the differences and potential associations in perinatal complications between pregnancies achieved through in-vitro fertilization-embryo transfer (IVF-ET) and natur…

BACKGROUND: Cesarean scar pregnancy (CSP) is an uncommon and potentially life-threatening form of ectopic pregnancy characterized by embryo implantation within the scar tissue of a prior cesarean delivery. OBJECTIVE: The aim of this study …

PURPOSE: Endometriosis (EMS) is a chronic gynecological disorder with unclear pathogenesis. While the vaginal and gut microbiomes are known to influence EMS, few studies have analyzed both microbiomes integrally. This study aims to characte…

Polypoid endometriosis (PEM) is a rare and distinctive variant of endometriosis, with ectopic endometrium presenting as a polypoid appearance. Due to the irregular shape of the mass on imaging, accompanied by obvious blood flow signals and …

CONTEXT: Polycystic ovary syndrome (PCOS) affects up to one-in-five reproductive-aged women and its global healthcare-related economic burden is substantial. The aim of this review was to summarise evidence of the cost-effectiveness of inte…

PURPOSE: This prospective multicenter observational study aimed to systematically collect and analyze data on the characteristics, treatments, and clinical outcomes of patients receiving infertility care at Korean Medicine (KM) hospitals an…

INTRODUCTION: Chronic pelvic pain (CPP) is a common condition involving multiple systems, characterized by complex manifestations and diverse clinical symptoms. The current treatment options for CPP are limited and may be only effective for…

OBJECTIVE: This study aimed to investigate whether endometrial thickness (EmT) change prognosticates the ongoing pregnancy rate (OPR) in hormonally prepared frozen-thawed embryo transfers (FETs) in women with treated intrauterine adhesion (…

OBJECTIVE: Less is known about the link between mortality and endometriosis, an often chronic, inflammatory gynecologic condition. We assessed the association between endometriosis and all-cause and cause-specific mortality using a retrospe…

PURPOSE: Endometriosis has been hypothesized to increase the risk of preeclampsia (PE) and eclampsia, although the exact mechanism of this relationship is not clear. This study aimed to further explore the potential association between endo…

OBJECTIVE: Oocyte cryopreservation represents an effective strategy for fertility preservation among women of reproductive age. The most consistent and robust body of evidence highlights female age at the time of oocyte retrieval as the sin…

BACKGROUND: Endometriosis (EM), a prevalent gynecological disorder in reproductive-age women, lacks reliable noninvasive diagnostic tools. EM may be detected by neutrophil extracellular traps (NETs), which are essential to inflammation and …

OBJECTIVE: Ectopic pregnancy (EP) is a significant global health concern and is associated with maternal mortality and compromised future fertility. This research aims to refine the assessment of EP's global impact and its associated inequa…

BACKGROUND: Klinefelter syndrome (KS) and Turner syndrome (TS) are chromosomal disorders characterized by gonadal dysgenesis, leading to male and female infertility, respectively. There is a significant gap in epidemiological data on infert…

BACKGROUND: This study aims to describe the global burden of female infertility, analyze its spatial and temporal trends, and offer targeted epidemiological insights to support the prevention and management of female infertility. METHODS: …

OBJECTIVE: To evaluate the effects of GnRH-a pretreatment with 1.5 mg or 3.75 mg, in combination with hormone replacement therapy (HRT), on pregnancy outcomes in women with polycystic ovary syndrome (PCOS) undergoing frozen embryo transfer …