Human reproduction open

STUDY QUESTION: What are the trial characteristics, geographic distribution, and selected methodological issues of randomized controlled trials (RCTs) in infertility published from 2012 to 2023? SUMMARY ANSWER: Of the 1425 infertility RCTs…

STUDY QUESTION: How important was the change in lumbar spine (L1-L4), femoral neck, and total hip bone mineral density (BMD) from post-treatment baseline values to 24 months after the end of treatment in PRIMROSE 1 and PRIMROSE 2 study part…

STUDY QUESTION: Are cardiovascular disease (CVD) risk factors causally associated with higher risk of infertility among women and men? SUMMARY ANSWER: We found evidence to support a causal relationship between smoking initiation and histor…

STUDY QUESTION: Does anogenital distance (AGD) - distance from the anus to the genitals - correlate from infancy (3 months) to the age of 9 years in boys and girls? SUMMARY ANSWER: In boys, AGD correlated from infancy to 9 years of age, wh…

STUDY QUESTION: Is acute haemoperitoneum that is managed conservatively a precursor of deep endometriosis? SUMMARY ANSWER: Our study provides evidence to suggest that acute haemoperitoneum may lead to the development of deep endometriosis …

STUDY QUESTION: Does abnormal serotonin homeostasis contribute to impaired endometrial decidualization in patients with recurrent implantation failure (RIF)? SUMMARY ANSWER: Abnormal serotonin homeostasis in patients with RIF, which is acc…

Study questionDoes endometrial compaction (EC) help predict pregnancy outcomes in those undergoing ART?Summary answerEC is associated with a significantly higher clinical pregnancy rate (CPR) and ongoing pregnancy rate (OPR), but this does …

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STUDY QUESTION: How should premature/primary ovarian insufficiency (POI) be diagnosed and managed based on the best available evidence from published literature? SUMMARY ANSWER: The current guideline provides 145 recommendations on symptom…

STUDY QUESTION: Which independent factors influence ICSI outcomes in patients with complete azoospermia factor c (AZFc) microdeletions? SUMMARY ANSWER: In patients with complete AZFc microdeletions, the sperm source, male LH, the type of i…

STUDY QUESTION: What are the quantitative, qualitative, and temporal patterns of retrograde mentruation? SUMMARY ANSWER: The extreme quantitative and qualitative heterogeneity of the available studies prevents the definitive conclusion tha…

The International Society of Ultrasound in Obstetrics and Gynecology (ISUOG) and International Deep Endometriosis Analysis (IDEA) group, the European Endometriosis League (EEL), the European Society for Gynaecological Endoscopy (ESGE), ESHR…

STUDY QUESTION: What is the effect of pretreatment with oral contraceptive pills (OCPs) on oocyte and embryo quality and pregnancy rates in women with polycystic ovary syndrome (PCOS) scheduled for IVF/ICSI cycles? SUMMARY ANSWER: In women…

STUDY QUESTION: Is SARS-CoV-2 infection in IVF-conceived early pregnancy associated with a higher risk of miscarriage? SUMMARY ANSWER: Infection with SARS-CoV-2 during early pregnancy in women conceiving by IVF may not be associated with a…

STUDY QUESTION: What are the odds of achieving pregnancy when adopting progestin-primed ovarian stimulation (PPOS)-related protocols combined with repetitive frozen-thawed transfer (FET) cycles in patients with different clinical characteri…

This cohort study follows the publication of a previous prospective pilot study by the same research group.Bean et al. (2019) followed 35 women with severe acute lower abdominal pain and detected de novo DIE at ultrasound follow-up in 4/6 (…

STUDY QUESTION: Which specific groups of women would not benefit from repeated frozen embryo transfers (FETs)? SUMMARY ANSWER: Women over 45 years of age should stop treatment after three FET attempts due to the absence of further benefits…

STUDY QUESTION: Are perinatal outcomes following fresh blastocyst versus fresh cleavage stage embryo transfer (ET) different in singletons, twins, and between singleton siblings? SUMMARY ANSWER: Singleton babies conceived following fresh b…

Study questionWhat are the roles of maternal 5,10-methylenetetrahydrofolate reductase (MTHFR) C677T/A1298C combination polymorphisms on the embryological and clinical outcomes of IVF/ICSI?Summary answerOur study reveals for the first time t…

STUDY QUESTION: Do children, adolescents, and young adults born after ART, including IVF, ICSI and frozen-thawed embryo transfer (FET), have an increased risk of cancer compared with children born to subfertile couples not conceived by ART …

STUDY QUESTION: What is the additional value of the comprehensive complication index (CCI) and ClassIntra system (classification for intraoperative adverse events (ioAEs)) in adverse event (AE) reporting in (deep) endometriosis (DE) surgery…

STUDY QUESTION: Is early rescue ICSI (E-RICSI) an effective and safe technique compared to conventional ICSI? SUMMARY ANSWER: Despite the higher multi-pronucleus (PN) rate compared to conventional ICSI, E-RICSI did not add extra risks to c…

Study questionDoes double vitrification and thawing of an embryo compromise the chance of live birth after a single blastocyst transfer?Summary answerThe live birth rate (LBR) obtained after double vitrification was comparable to that obtai…

STUDY QUESTION: What are the dynamic expression features of plasma microRNAs (miRNAs) during the peri-implantation period in women with successful pregnancy via single frozen-thawed blastocyst transfer? SUMMARY ANSWER: There is a significa…

Study questionWhat is the present performance of artificial intelligence (AI) decision support during embryo selection compared to the standard embryo selection by embryologists?Summary answerAI consistently outperformed the clinical teams …