Human reproduction open

STUDY QUESTION: Is telehealth cognitive behavioural therapy (CBT) or yoga effective in improving health-related quality of life (HRQoL) and secondary outcomes for endometriosis? SUMMARY ANSWER: Endometriosis-tailored CBT is superior to edu…

STUDY QUESTION: What is the incidence of triploidy and genome-wide uniparental disomy (gwUPD) in human embryos currently undetected by conventional preimplantation genetic testing (PGT)? SUMMARY ANSWER: Triploidy and gwUPD were detected in…

Study questionAre previously proposed vaginal microbial community state types (CSTs) valid predictors of IVF success, or do alternative microbial signatures provide stronger associations?Summary answerPreviously proposed CSTs as predictors …

STUDY QUESTION: Does polycystic ovary syndrome (PCOS) represent a human model for reproductive longevity? SUMMARY ANSWER: Asian women with PCOS have enhanced ovarian reserve and ART outcomes, even at an advanced maternal age. WHAT IS KNOW…

STUDY QUESTION: Do novel per- and poly-fluoroalkyl substances (Novel PFAS) have associations with premature ovarian insufficiency (POI)? SUMMARY ANSWER: Hexafluoropropylene oxide dimer acid (HFPO-DA), perfluorobutanoic acid (PFBA), perfluo…

Study questionIs there an association between dydrogesterone exposure during early pregnancy and the reporting of birth defects?Summary answerThis observational analysis based on global safety data showed an increased reporting of birth def…

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STUDY QUESTION: Is there a difference in uterine functional determinants between women with fibroids and women without myometrial pathology? SUMMARY ANSWER: Women with uterine fibroids consistently exhibit altered uterine functional determ…

STUDY QUESTION: What are the impacts of different male infertility factors on embryological, cumulative pregnancy and neonatal outcomes of IVF/ICSI cycles? SUMMARY ANSWER: Some severe male infertility factors, i.e. severe oligoasthenozoosp…

Study questionDoes the type of embryo culture medium affect the birthweight of newborns conceived by ART?Summary answerAfter fresh embryo transfers, singleton newborns in the G5 and HTF groups exhibited higher birthweight z-scores and incre…

STUDY QUESTION: Is there an association between changes in endometrial thickness (EMT) following progesterone administration and pregnancy outcomes in frozen-thawed embryo transfers (FETs) at Day 3 (D3) and blastocyst stages? SUMMARY ANSWE…

STUDY QUESTION: What is the effect of hCG on the epigenetic profile and the expression of other molecular factors in endometrial stromal cells (ESCs)? SUMMARY ANSWER: Our findings suggest that hCG treatment alters the molecular environment…

STUDY QUESTION: Do activated fibroblasts expressing fibroblast activation protein-α (FAP) - which is traceable in positron emission topography/computed topography (PET/CT) - play a role in the microenvironment of endometriosis? SUMMARY ANS…

BACKGROUND: Endometriosis is a chronic disease that can compromise fertility in up to 30-50% of affected patients, and it is estimated that patients affected by endometriosis represent about 10% of patients undergoing ART treatments. The hy…

STUDY QUESTION: What is the hormone receptor profile of adenomyosis lesions in comparison to correctly located endometrium? SUMMARY ANSWER: Adenomyosis lesions exhibit increased oestrogen receptor (ER) expression compared to the eutopic en…

STUDY QUESTION: What is the evidence available concerning gut and reproductive tract microbiomes in patients with endometriosis and what are the methodological approaches employed in microbiome studies on endometriosis? SUMMARY ANSWER: The…

STUDY QUESTION: Does the molecular composition of uterine fluid extracellular vesicles (UF-EVs) reflect endometrial tissue changes across the menstrual cycle? SUMMARY ANSWER: Concordance between endometrial tissue and UF-EVs exists on miRN…

Nearly 200 million people worldwide suffer from infertility. Disparities exist between developed and developing countries due to differences in the availability of infertility care, different reimbursement policies and socio-cultural differ…

STUDY QUESTION: Do all ectopic endometrial lesions (endometriosis and adenomyosis) universally have activated estrogen signaling? SUMMARY ANSWER: Estrogen signaling diminishes concordantly with increased fibrosis in ectopic endometrium, wi…

STUDY QUESTION: Can third-generation sequencing (TGS)-based polar body (PB) analysis serve as a viable alternative to conventional trophectoderm (TE) biopsy for preimplantation genetic testing for aneuploidy (PGT-A)? SUMMARY ANSWER: This s…

STUDY QUESTION: What is the return rate for the use of ovarian tissue cryopreserved for fertility preservation prior to gonadotoxic treatment? SUMMARY ANSWER: The return rate for the use of ovarian tissue cryopreserved for fertility preser…

STUDY QUESTION: Does cancer treatment during pregnancy affect gonadal development in the exposed foetus? SUMMARY ANSWER: Our systematic review revealed that exposure in utero to many cancer therapies does negatively impact gonadal developm…

STUDY QUESTION: Are different types of thyroid cancer treatment among young women associated with adverse reproductive outcomes? SUMMARY ANSWER: All types of thyroid cancer treatment were associated with infertility diagnosis and early men…