Human reproduction open

STUDY QUESTION: Could the miRNA cargo of extracellular vesicles (EVs) secreted by eutopic endometrium from women with endometriosis be involved in the pregnancy complications related to endometriosis? SUMMARY ANSWER: EVs secreted by eutopi…

STUDY QUESTION: Can oocyte maturation be adapted to a phenotypic assay within a drug screening pipeline to identify compounds that block meiotic progression for female non-hormonal contraceptive drug discovery? SUMMARY ANSWER: A complex ph…

STUDY QUESTION: How does benzodiazepine use during an IVF cycle affect pregnancy outcomes? SUMMARY ANSWER: Benzodiazepine use was neither positively nor adversely associated with IVF pregnancy outcomes overall. WHAT IS KNOWN ALREADY: Benz…

STUDY QUESTION: What is the current landscape of randomized controlled trials (RCTs) evaluating stem cell-based therapies for women's reproductive diseases, and how effectively has preclinical research informed their clinical translation? …

STUDY QUESTION: Which surgical technique for endometrioma has the least detrimental effect on ovarian reserves? SUMMARY ANSWER: Drainage with hemostatic sealants and cystectomy with ovarian suturing were associated with relatively smaller …

STUDY QUESTION: Does the analysis of endometrial microbes provide the same information when using DNA or RNA sequencing-based techniques? SUMMARY ANSWER: DNA vs RNA-based microbial analysis techniques demonstrated significant microbial com…

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STUDY QUESTION: Does cost-to-baby, expressed as a percentage of median household income (HHI), predict population-level utilization of ART across countries? SUMMARY ANSWER: ART affordability follows a power-law relationship with population…

STUDY QUESTION: Is endometrioma diameter associated with ovarian reserve, as reflected by serum anti-Müllerian hormone (AMH) levels, in women of reproductive age with no history of ovarian surgery? SUMMARY ANSWER: Across 30 independent coh…

STUDY QUESTION: What is the optimal timing of progesterone exposure to achieve live births for day-6 blastocysts in artificial frozen-thawed embryo transfer (FET) cycles? SUMMARY ANSWER: Live birth rates (LBRs) were comparable between day-…

STUDY QUESTION: Does adding vaginal estradiol to standard progesterone luteal phase support improve ongoing pregnancy rates in normal-responder IVF/ICSI patients undergoing GnRH antagonist cycles? SUMMARY ANSWER: The addition of vaginal es…

The pathogenesis of endometriosis and adenomyosis remains incompletely understood, and a notable gap persists between the reported heritability and the disease variation explained by identified susceptibility loci. In this manuscript, we sh…

STUDY QUESTION: Does PIEZO1 play any role in adenomyosis-associated dysmenorrhea? SUMMARY ANSWER: PIEZO1 downregulation in the myometrium reduces the expression of endothelial nitric oxide synthase (eNOS) and nitric oxide (NO) production, …

Study questionDoes intercornual distance (ICD), as reflected by intrauterine stent size during hysteroscopic adhesiolysis, have an association with reproductive outcomes and provide information for postoperative risk stratification in women…

STUDY QUESTION: Does IVF worsen pelvic pain in women with endometriosis? SUMMARY ANSWER: Nearly half of women with endometriosis reported perceived worsening of pelvic pain after IVF. WHAT IS KNOWN ALREADY: Prior studies generally suggest…

STUDY QUESTION: Are endometriotic lesions affecting bilateral organs or anatomical structures distributed symmetrically on both sides of the body? SUMMARY ANSWER: The left-sided preponderance of pelvic endometriotic lesions, and the right-…

STUDY QUESTION: What is the likelihood of future childbirth in women undergoing unilateral oophorectomy (UO) for benign indications, when compared to age-matched women with intact ovaries? SUMMARY ANSWER: A significantly reduced likelihood…

STUDY QUESTION: Was the efficacy of linzagolix, observed at 6 months in women with endometriosis-associated pain, maintained when administered for an additional 6 months? SUMMARY ANSWER: Efficacy from this extension study complements the r…

STUDY QUESTION: Can the transcriptomic profile of small extracellular vesicles (sEVs) derived from menstrual fluid (MF) provide preliminary insights into their potential roles as biomarkers and mediators in endometriosis (EM) progression? …

STUDY QUESTION: Does late-night, modified-release hydrocortisone (MR-HC) improve biochemical control and restore menstrual regularity in women with non-classic congenital adrenal hyperplasia (NCCAH)? SUMMARY ANSWER: Once-daily MR-HC substa…

STUDY QUESTION: Are bioactive human-equivalent doses (HEDs) of perfluorooctane sulfonate (PFOS), derived from long-term low-level in vitro exposure of human granulosa cells comparable to HEDs inferred from follicular fluid PFOS concentratio…

STUDY QUESTION: Can a model be developed to predict natural conception leading to live birth over a period of 12 months in couples with different causes of infertility? SUMMARY ANSWER: We developed and validated a novel clinical prediction…

BACKGROUND: Although assisted reproductive technologies have enabled millions of births worldwide, in vitro embryo culture systems remain a simplified and static approximation of the highly dynamic environment of the female reproductive tra…