Frontiers in medicine

Finite element modeling (FEM) is a critical tool in biomechanics and biomedical engineering, offering valuable insights where in vivo or ex vivo investigations are not possible. This review specifically highlights the diverse applications o…

BACKGROUND: Endometriosis is a common, chronic, estrogen-dependent gynecological disorder that significantly affects patients' quality of life. However, the disease burden and its trends may be undergoing significant changes, and comprehens…

BACKGROUND: This study aimed to assess the evolution, trends, and research hotspots of publications related to natural killer (NK) cells and miscarriage. METHODS: The literature on NK cells and miscarriage was retrieved from the Web of Sci…

OBJECTIVE: The aim of this study was to compare the effects of different endometrial treatment regimens on the outcome of frozen embryo transfer (FET). METHODS: A retrospective analysis of 1,454 FET cycles was conducted. Subgroups were str…

Hepatolenticular Degeneration (HLD) is a rare condition caused by a genetic copper metabolism disorder and a basal ganglia-dominated degenerative brain disease. Its characteristic clinical features include progressive extrapyramidal symptom…

BACKGROUND: Current therapeutic approaches for premature ovarian failure (POF) are often inadequate in clinical practice and some raise ethical concerns. Human umbilical cord mesenchymal stem cells (hUC-MSCs) have emerged as a preferred opt…

BACKGROUND: This study investigated the safety and efficacy of hysteroscopic sutureless fixation of the levonorgestrel-releasing intrauterine system (LNG-IUS) for treating heavy menstrual bleeding (HMB), providing a viable therapeutic optio…

BACKGROUND: Fatty acid metabolism plays a major role in several inflammatory diseases such as endometriosis. However, its specific mechanism in endometriosis remains unclear. Therefore, this study aimed to investigate the hub genes involved…

BACKGROUND: Obesity is a global health challenge that complicates gynecological surgery. Vaginal natural orifice transluminal endoscopic surgery (v-NOTES) offers a minimally invasive approach to total hysterectomy (TH), but its safety and e…

BACKGROUND: Endometriosis is often diagnosed late and presents significant challenges in clinical treatment. A comprehensive investigation of the cellular classification and composition of endometriosis is essential for studying its diagnos…

INTRODUCTION: Ovarian cancer is a major diagnostic problem because it is asymptomatic in its early stages and requires subjective interpretation of ultrasound images. METHODS: This research presents the EfficientOvaNet framework, a deep le…

Intravenous leiomyomatosis (IVL) is a rare benign tumor originating from the smooth muscle of the uterus. Tumor cells spread along the veins, which may involve the uterine veins, pelvic veins, inferior vena cava, and even the right atrium. …

OBJECTIVE: This study aimed to assess the impact of performing diagnostic hysteroscopy prior to the first in vitro fertilization (IVF) cycle on clinical pregnancy rates and live birth rates. METHODS: A retrospective descriptive study was c…

BACKGROUND: Pelvic organ prolapse (POP) significantly impacts women's quality of life, with laparoscopic sacrocolpopexy (LSC) considered the gold standard for treatment. However, LSC carries risks of complications, prompting exploration of …

Cervicovaginal anomalies are rare and form 4-7% of the Müllerian anomalies. Traditionally, cervicovaginal agenesis/dysgenesis had been treated by hysterectomy due to the high risks of restenosis and sepsis which are associated with cervical…

INTRODUCTION: Adenomyosis is a chronic gynecological disorder characterized by the infiltration of ectopic endometrial tissue into the myometrium, affecting approximately 20-35% of women of reproductive age. Although hormonal therapy and su…

OBJECTIVE: Endometriosis is a multifactorial disease that affects mainly women of reproductive age. It is unclear whether each form of pelvic endometriosis is an independent entity and whether a spatial relationship between all three endome…

Herlyn-Werner-Wunderlich syndrome (HWWS) combined with pelvic mesothelial cyst is a rare condition that can be easily misdiagnosed. Our center presents a case study of this disease to provide clinicians with valuable insights for accurate d…

We report two cases of heterotopic intramural ectopic pregnancy (HIMP) following multiple abortions, with lesions located near the uterine fundus or uterine horn. These cases are particularly challenging to diagnose using early two-dimensio…

Gynecologic disorders, such as cervical and ovarian tumors, uterine fibroids, and endometriosis, present significant clinical challenges due to frequent recurrence, emerging chemoresistance, and undesirable effects associated with prolonged…

BACKGROUND: Predicting clinical pregnancy outcomes in patients with diminished ovarian reserve (DOR) undergoing in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) remains challenging owing to the unique characteristics of th…

BACKGROUND: Inflammatory Bowel Disease (IBD) is a chronic, idiopathic inflammatory disorder of the intestines. Oxymatrine (OMT) is a naturally active substance found in the desiccated roots of Sophora flavescens. It possesses anti-tumor, an…

OBJECTIVE: To analyze the clinicopathological features and prognostic factors of intravenous Leiomyomatosis (IVL), a rare yet recurrent disease. METHODS: This retrospective observational study enrolled 43 patients with pathologically confi…

Adenomyosis is a common gynecological condition affecting women of reproductive age, posing significant diagnostic challenges due to its diverse clinical presentations. This extended opinion study critically reviews the diagnostic methods f…

BACKGROUND: Alarelin acetate, a synthetic gonadotropin-releasing hormone (GnRH) analogue, is widely used to manage endometriosis and hormone-sensitive malignancies. Although its safety profile is generally favorable, we report the first doc…