Frontiers in medicine

Endometriosis is the commonest benign gynecological condition, affecting about 10% of women and girls of reproductive age worldwide [1] . This is a chronic disorder affected by estrogen regulation and presents with symptoms like dysmenorrhe…

BACKGROUND: Myofascial pelvic pain syndrome (MPPS) is a common but often underdiagnosed cause of chronic pelvic pain in women, significantly affecting quality of life. Early and accurate identification of patients at risk is essential for i…

Antibodies have been widely used globally over the past decade and play an increasingly important role in modern medicine. Notably, significant advancements have been achieved in the realm of gynecology, particularly in gynecological cancer…

OBJECTIVE: To investigate the construction and clinical application value of Nomogram predictive model for recurrent spontaneous abortion (RSA) based on the expressions of MALAT1 (Metastasis Associated Lung Adenocarcinoma Transcript 1), miR…

Background/objectivesCesarean scar pregnancy (CSP) is a rare but increasingly prevalent form of ectopic pregnancy, often associated with severe postoperative complications. Current research lacks robust tools to predict these complications.…

Goserelin is widely used for prostate cancer, but drug-induced liver injury (DILI) has been rarely reported. We present a patient who developed ALT/AST elevations after each subcutaneous injection, followed by improvement after withdrawal a…

OBJECTIVE: This study aimed to compare the perioperative outcomes of single-incision laparoscopic surgery (SILS) and dual-port laparoscopic myomectomy in patients with solitary uterine fibroids. METHODS: This retrospective observational st…

BACKGROUND: Hysterectomy is a common major gynecological surgery. Total laparoscopic hysterectomy (TLH) has become a preferred method over traditional approaches due to its minimally invasive nature and reduced postoperative complications. …

BACKGROUND: This study aimed to observe the effect of dexmedetomidine on the median effective concentration (EC50) of ropivacaine for postoperative analgesia in ultrasound-guided transversus abdominis plane block. METHODS: Patients undergo…

BACKGROUND: In vitro fertilization-embryo transfer (IVF-ET) is a core assisted reproductive technology (ART) for infertile couples, but poor endometrial receptivity (ER) severely impairs embryo implantation and reduces success rates, imposi…

BACKGROUND: To evaluate the efficacy and long-term safety of treatment with dienogest in patients with endometrioma. METHODS: Patients with endometrioma-related chronic pelvic pain were included in this retrospective study from March 2018 …

OBJECTIVE: This retrospective cohort study aimed to investigate the effects of different colony-stimulating factor regimens in patients with recurrent implantation failure who underwent euploid embryo transfer. METHODS: In total, 293 women…

BACKGROUND: Chronic pain afflicts approximately 20% of the global adult population and is frequently undertreated, with available pharmacologic options often associated with significant long-term adverse effects. Although omega-3 fatty acid…

OBJECTIVE: The study aimed to explore the effects of platelet-rich plasma (PRP) gel on vaginal microecology and stump healing, as well as its underlying mechanism. METHODS: From December 2022 to August 2024, 100 patients who underwent lapa…

BACKGROUND: This phase 2 trial comprised dose exploration (stage 1) and dose confirmation stages (stage 2) to determine the safety and efficacy of HSK21542 in patients undergoing laparoscopic abdominal surgery. METHODS: In stage 1, patient…

OBJECTIVE: A growing number of research papers have looked at the influence of exercise on pain severity in people with primary dysmenorrhea, but the findings have been inconsistent. The purpose of this research was to thoroughly evaluate t…

BACKGROUND: Endometriosis can cause gastrointestinal symptoms that sometimes lead to incorrect diagnosis of irritable bowel syndrome (IBS). Receptors of thyroid-stimulating hormone (TSH) are found in the endometrium and are overexpressed in…

BACKGROUND: Adenomyosis is often associated with abnormal uterine bleeding (AUB), which can lead to anemia. Recurrent bleeding, especially in the presence of cerebral infarction risk, may exacerbate the likelihood of cerebral infarction thr…

This narrative review examines the therapeutic potential of Erastin and its derivatives for endometriosis (EMS) by integrating mechanistic, preclinical, and translational perspectives. We conducted a focused review of literature from PubMed…

Endometriosis is the growth of endometrial-like tissue at non-uterine locations, primarily within the peritoneal cavity. The disease can have diverse presentations with superficial lesions, deep invading lesions and ovarian cysts (endometri…

OBJECTIVE: To compare the outcomes of hysterectomy performed via traditional inpatient procedure versus day-care procedure with a focus on surgical time, post-operative recovery, costs, and patient satisfaction, using propensity score match…

INTRODUCTION: Recent studies emphasize the role of immune dysregulation and inflammation in endometriosis (ES). While hormonal therapy remains the primary treatment, emerging research is exploring synergistic approaches that target inflamma…

BACKGROUND: Endometriosis is a prevalent gynecological disorder that is estimated to affect approximately 10% of women of childbearing age globally. However, the condition remains significantly under-or misrecognized, and the mean time to d…