Ivan Nagaev

No ORCID on file · 2 papers in corpus · active 2020-2024

Study types

  • article 2

Condition tags

  • endometriosis 2
  • infertility 1
article 2024
Endometriotic Tissue-derived Exosomes Downregulate NKG2D-mediated Cytotoxicity and Promote Apoptosis: Mechanisms for Survival of Ectopic Endometrial Tissue in Endometriosis
Journal of immunology (Baltimore, Md. : 1950) ·doi:10.4049/jimmunol.2300781

Endometriosis, affecting 10% of women, is defined as implantation, survival, and growth of endometrium-like/endometriotic tissue outside the uterine cavity, causing inflammation, infertility, pain, and susceptibility to ovarian cancer. Desp…

article 2020
Enhanced local and systemic inflammatory cytokine mRNA expression in women with endometriosis evokes compensatory adaptive regulatory mRNA response that mediates immune suppression and impairs cytotoxicity
American journal of reproductive immunology (New York, N.Y. : 1989) ·doi:10.1111/aji.13298

PROBLEM: Endometriosis is a disease characterized by ectopic implantation of endometrium and impaired immune responses. To explore its pathogenic mechanisms, we studied the local and systemic cytokine mRNA profiles and their role in the imm…