Lucia Mincheva‐Nilsson

other 2026

Enhanced CD56 Expression and Increased Number of CD56+bright Cells in the Peripheral Blood of Untreated Endometriosis Patients

American journal of reproductive immunology (New York, N.Y. : 1989) ·doi:10.1111/aji.70214

PROBLEM: NK-cell dysfunction in endometriosis is suggested to contribute to the survival of ectopic endometrial tissue. However, the underlying causes of this impairment remain unclear. NK cells are divided into: CD56+bright, which produce …

review 2026

Immune mechanisms in the pathogenesis of endometriosis: a comprehensive analysis of the role of NK cells, cytokines, and extracellular vesicles/exosomes

Frontiers in immunology ·doi:10.3389/fimmu.2026.1885409

INTRODUCTION: Endometriosis is a chronic, estrogen-dependent inflammatory disorder affecting approximately 10% of women of reproductive age. Retrograde menstruation is widely accepted as a primary mechanism for ectopic endometrial seeding; …

article 2024

Endometriotic Tissue-derived Exosomes Downregulate NKG2D-mediated Cytotoxicity and Promote Apoptosis: Mechanisms for Survival of Ectopic Endometrial Tissue in Endometriosis

Journal of immunology (Baltimore, Md. : 1950) ·doi:10.4049/jimmunol.2300781

Endometriosis, affecting 10% of women, is defined as implantation, survival, and growth of endometrium-like/endometriotic tissue outside the uterine cavity, causing inflammation, infertility, pain, and susceptibility to ovarian cancer. Desp…

article 2020

Enhanced local and systemic inflammatory cytokine mRNA expression in women with endometriosis evokes compensatory adaptive regulatory mRNA response that mediates immune suppression and impairs cytotoxicity

American journal of reproductive immunology (New York, N.Y. : 1989) ·doi:10.1111/aji.13298

PROBLEM: Endometriosis is a disease characterized by ectopic implantation of endometrium and impaired immune responses. To explore its pathogenic mechanisms, we studied the local and systemic cytokine mRNA profiles and their role in the imm…