Matthew Rosser

No ORCID on file · 13 papers in corpus · active 2011-2024

Study types

  • article 6
  • preprint 4
  • dissertation 1
  • other 1
  • review 1

Condition tags

  • endometriosis 13
  • chronic_pelvic_pain 1
preprint 2024
Preclinical testing of RRx-001 in mouse models of experimental endometriosis reveals promising therapeutic impacts
·doi:10.1101/2024.08.12.607591

Endometriosis is a chronic inflammatory condition characterised by the presence of ectopic endometrial-like tissue (lesions), reduced fertility and chronic pain. Impacting both the health and psycho-social functioning of millions of women w…

preprint 2024
Single-cell analysis identifies distinct macrophage phenotypes associated with pro-disease and pro-resolving functions in the endometriotic niche
·doi:10.1101/2024.03.07.583861

Abstract Endometriosis negatively impacts the health-related quality of life of 190 million women worldwide. Novel advances in non-hormonal treatments for this debilitating condition are desperately needed. Macrophages play a vital role in …

other 2024
Single-cell analysis identifies distinct macrophage phenotypes associated with prodisease and proresolving functions in the endometriotic niche
Proceedings of the National Academy of Sciences of the United States of America ·doi:10.1073/pnas.2405474121

Endometriosis negatively impacts the health-related quality of life of 190 million women worldwide. Novel advances in nonhormonal treatments for this debilitating condition are desperately needed. Macrophages play a vital role in the pathop…

preprint 2021
(no title)

Macrophages are intimately involved in the pathophysiology of endometriosis, a chronic inflammatory disorder characterized by the growth of endometrial-like tissue (lesions) outside the uterus. By combining genetic and pharmacological monoc…

article 2021
Macrophages inhibit and enhance endometriosis depending on their origin
Proceedings of the National Academy of Sciences of the United States of America ·doi:10.1073/pnas.2013776118

Macrophages are intimately involved in the pathophysiology of endometriosis, a chronic inflammatory disorder characterized by the growth of endometrial-like tissue (lesions) outside the uterus. By combining genetic and pharmacological monoc…

review 2020
Endometriosis-Associated Pain – Do Preclinical Rodent Models Provide a Good Platform for Translation?
Advances in anatomy, embryology, and cell biology ·doi:10.1007/978-3-030-51856-1_3
preprint 2020
Macrophages inhibit and enhance endometriosis depending on their origin
·doi:10.1101/2020.04.30.070003

Abstract Macrophages are intimately involved in the pathophysiology of endometriosis, a chronic inflammatory disorder characterized by the growth of endometrial-like tissue (lesions) outside the uterus. By combining genetic and pharmacologi…

article 2017
Do bioactive lipids play a role in leuprolide acetate treatment of endometriosis

Do bioactive lipids play a role in leuprolide acetate treatment of endometriosis

article 2016
Prostaglandin EP4 receptors: a possible therapeutic target for endometriosis

Prostaglandin EP4 receptors: a possible therapeutic target for endometriosis

article 2015
A clinical update on Endometriosis
article 2014
Lipidomic profiling of omental adipose, endometrium and peritoneal fluid from women with and without endometriosis.
article 2011
The emerging role of epigenetics and miRNAs in endometriosis
·doi:10.1586/eog.11.32

Endometriosis is a complex and multifactoral disease with the evidence indicating that its pathophysiology is fractured and separated, often leading to it being referred to as the ‘disease of theories’. Here we present evidence on the invol…

dissertation 2011
The emerging role of epigenetics in the aetiology of endometriosis.

BACKGROUND. Endometriosis is a very common but poorly understood disease. Defined as the presence of tissue resembling endometrial glands and stroma found in various locations around the body the disease manifests as implants which periodic…