Jeffrey W. Pollard

preprint 2021

Macrophages are intimately involved in the pathophysiology of endometriosis, a chronic inflammatory disorder characterized by the growth of endometrial-like tissue (lesions) outside the uterus. By combining genetic and pharmacological monoc…

article 2021

Macrophages inhibit and enhance endometriosis depending on their origin

Proceedings of the National Academy of Sciences of the United States of America ·doi:10.1073/pnas.2013776118

Macrophages are intimately involved in the pathophysiology of endometriosis, a chronic inflammatory disorder characterized by the growth of endometrial-like tissue (lesions) outside the uterus. By combining genetic and pharmacological monoc…

preprint 2020

Macrophages inhibit and enhance endometriosis depending on their origin

·doi:10.1101/2020.04.30.070003

Abstract Macrophages are intimately involved in the pathophysiology of endometriosis, a chronic inflammatory disorder characterized by the growth of endometrial-like tissue (lesions) outside the uterus. By combining genetic and pharmacologi…

article 2015

Activation of protein synthesis in mouse uterine epithelial cells by estradiol-17β is mediated by a PKC–ERK1/2–mTOR signaling pathway

Proceedings of the National Academy of Sciences of the United States of America ·doi:10.1073/pnas.1418973112

The uterine epithelium of mice and humans undergoes cyclical waves of cell proliferation and differentiation under the regulation of estradiol-17β (E2) and progesterone (P4). These epithelial cells respond to E2 with increased protein and D…