Bortolini MC

No ORCID on file · 3 papers in corpus · active 2012-2015

Study types

  • article 1

Condition tags

  • endometriosis 1
  • infertility 1
2015
Genetic Variations in the TP53 Pathway in Native Americans Strongly Suggest Adaptation to the High Altitudes of the Andes.
PloS one ·doi:10.1371/journal.pone.0137823

The diversity of the five single nucleotide polymorphisms located in genes of the TP53 pathway (TP53, rs1042522; MDM2, rs2279744; MDM4, rs1563828; USP7, rs1529916; and LIF, rs929271) were studied in a total of 282 individuals belonging to Q…

2012
The TP53 fertility network.
Genetics and molecular biology ·doi:10.1590/s1415-47572012000600008

The TP53 gene, first described in 1979, was identified as a tumor suppressor gene in 1989, when it became clear that its product, the p53 nuclear phosphoprotein, was frequently inactivated in many different forms of cancers. Nicknamed "guar…

article 2012
TP53 PIN3 and PEX4 polymorphisms and infertility associated with endometriosis or with post-in vitro fertilization implantation failure
Cell death & disease ·doi:10.1038/cddis.2012.116

p53 has a crucial role in human fertility by regulating the expression of leukemia inhibitory factor (LIF), a secreted cytokine critical for blastocyst implantation. To examine whether TP53 polymorphisms may be involved with in vitro fertil…