Pierre Hainaut

TP53 is the most frequently mutated gene in human cancers, and germline mutations in TP53 cause Li-Fraumeni syndrome (LFS), a hereditary predisposition to diverse cancers. Accurate annotation of TP53 mutations based on their survival effe…

The TP53 gene, first described in 1979, was identified as a tumor suppressor gene in 1989, when it became clear that its product, the p53 nuclear phosphoprotein, was frequently inactivated in many different forms of cancers. Nicknamed "guar…

p53 has a crucial role in human fertility by regulating the expression of leukemia inhibitory factor (LIF), a secreted cytokine critical for blastocyst implantation. To examine whether TP53 polymorphisms may be involved with in vitro fertil…