Nair HB

No ORCID on file · 6 papers in corpus · active 2008-2019

Study types

  • article 4
  • other 1

Condition tags

  • endometriosis 4
2019
EC313-a tissue selective SPRM reduces the growth and proliferation of uterine fibroids in a human uterine fibroid tissue xenograft model.
Scientific reports ·doi:10.1038/s41598-019-53467-w

Uterine fibroids (UFs) are associated with irregular or excessive uterine bleeding, pelvic pain or pressure, or infertility. Ovarian steroid hormones support the growth and maintenance of UFs. Ulipristal acetate (UPA) a selective progestero…

article 2016
An efficient model of human endometriosis by induced unopposed estrogenicity in baboons
Oncotarget ·doi:10.18632/oncotarget.7516

// Hareesh B. Nair 1 , Robert Baker 2 , Michael A. Owston 2 , Renee Escalona 2 , Edward J. Dick 2 , John L. VandeBerg 2 and Klaus J. Nickisch 1 1 Evestra, Inc., San Antonio, TX, USA 2 Southwest National Primate Research Center, Texas Biomed…

other 2013
Synthesis and antiprogestational properties of novel 17-fluorinated steroids
Steroids ·doi:10.1016/j.steroids.2013.04.003

Progesterone receptor (PR) plays a key role in reproductive functions, and compounds that inhibit progesterone action (antiprogestins) have potential use in the treatment of estrogen- and progesterone-dependent diseases, including uterine l…

article 2012
Increased expression of macrophage colony–stimulating factor and its receptor in patients with endometriosis
Fertility and sterility ·doi:10.1016/j.fertnstert.2012.02.007

ObjectiveTo investigate the expression and regulation of colony-stimulating factor 1 (CSF-1) and its receptor, C-FMS, in endometriosis.DesignIn vivo and vitro study.SettingUniversity-based academic medical center.Patient(s)Reproductive-age …

article 2009
Induction of endometrial epithelial cell invasion and c-fms expression by transforming growth factor beta
Molecular human reproduction ·doi:10.1093/molehr/gap043

Transforming growth factor beta 1 (TGF-beta1) levels are increased in the peritoneal fluid of endometriosis patients, and endometrial cells express TGF-beta signaling components; however, little is known regarding the role of TGF-beta in en…

article 2008
Modeling the early endometriotic lesion: mesothelium-endometrial cell co-culture increases endometrial invasion and alters mesothelial and endometrial gene transcription
Fertility and sterility ·doi:10.1016/j.fertnstert.2007.09.047

ObjectiveTo determine the role of peritoneal mesothelial cells (PMCs) in the process of endometrial invasion into the peritoneum and to evaluate gene expression after endometrial-PMC co-culture.DesignIn vitro study.SettingUniversity laborat…