Khalid S. Khan

INTRODUCTION: Endometriosis is a common gynaecological disease characterised by pain and subfertility. Randomised controlled trials evaluating treatments for endometriosis have reported many different outcomes and outcome measures. This var…

(Abstracted from Am J Obstet Gynecol 2016;214(4):452–464) Endometriosis impairs health-related quality of life. It occurs in 1 of 10 women.

OBJECTIVE: We reviewed the outcomes and outcome measures reported in randomized controlled trials and their relationship with methodological quality, year of publication, commercial funding, and journal impact factor. DATA SOURCES: We sear…

PURPOSE OF REVIEW: Chronic pelvic pain (CPP) has an annual prevalence of 38/1000 in the UK, with coexisting pathologies often present. Diagnostic laparoscopy has long been the gold standard diagnostic test, but with up to 40% showing no abn…

AIM: To identify radiological parameters that should be reported on gynaecological MRI in order to create a standardized assessment pro forma for reporting CPP, which may be used in clinical practice. METHODS: Chronic pelvic pain (CPP) in …

BACKGROUND: Bladder pain syndrome (BPS), a condition with no gold standard diagnosis, comprises of a cluster of signs and symptoms. Bladder filling pain and bladder wall tenderness are two basic clinical features, present in a high number o…

PURPOSE OF REVIEW: The term idiopathic is often used to describe a disease with no identifiable cause. It may be a diagnosis of exclusion; however, what specific minimum investigations need to be performed to define idiopathic is not always…

BACKGROUND: Chronic pelvic pain (CPP), a common gynaecological presentation, may be due to bladder pain syndrome (BPS) or the co-existence of BPS and endometriosis, known as the 'evil twins syndrome'. OBJECTIVES: To estimate the prevalence…

Adenomyosis is frequent during the evaluation of infertile women. Present evidence suggests that adenomyosis has a negative impact on female fertility. Limited data from uncontrolled studies suggest that treatment of adenomyosis may improve…

Gynaecological surgery is constantly evolving. To inform practicewith high-impact research, clinicians need to focus on areas ofimportance. Surveys of specialist members of the British Society ofGynaecological Endoscopy have revealed a rang…

Gynaecological surgery is constantly evolving. To inform practice with high-impact research, clinicians need to focus on areas of importance. Surveys of specialist members of the British Society of Gynaecological Endoscopy have revealed a r…

According to the original receptor occupancy theory proposed by Clark in the 1930s, the percent occupancy of total available receptors by an agonist is linearly related to the response (or effect). However, the first recognition of "recepto…

Chronic pelvic pain (CPP), a common cause of disability in women, is a condition best viewed in the biopsychosocial framework. Psychological interventions are frequently considered alongside medical and surgical treatments. Our objective wa…

#### Summary points Chronic pelvic pain in women is a debilitating condition that impairs quality of life. Studies using various definitions estimated that its prevalence ranges from 2.1% to 24% of the female population worldwide.1 It is a…

Abstract Randomized control trials (RCTs) are widely accepted as a gold standard for scientific evaluation of all treatments. Benign gynecological conditions such as chronic pelvic pain, heavy menstrual bleeding, and subfertility can be tre…

BACKGROUND: There have been conflicting results in randomized trials of the effects of laparoscopic uterosacral nerve ablation (LUNA) in chronic pelvic pain. Our objective was to perform a meta-analysis using individual patient data (IPD) t…

BACKGROUND: Adenomyosis is a common condition that causes substantial morbidity. Until recently, the reference standard for a definitive diagnosis was histology of hysterectomy specimens. Ultrasound and magnetic resonance imaging (MRI) may …

CONTEXT: Chronic pelvic pain is a common condition with a major effect on health-related quality of life, work productivity, and health care use. Operative interruption of nerve trunks in the uterosacral ligaments by laparoscopic uterosacra…

In this chapter, we address future research topics by examining clinically relevant issues; basic research of the endocrine aspects of endometrial tissue will not be dealt with. We focus on studies of diagnostic strategies, quality of life …

OBJECTIVE: To assess the effects of aromatase inhibitors in women symptomatic of pain with endometriosis. DESIGN: A systematic review of published literature. MATERIAL AND METHODS: We conducted a comprehensive literature search to identif…

BACKGROUND: Currently, there are a number of clinical trials, but no international collaboration for collating research on effectiveness of laparoscopic uterosacral nerve ablation (LUNA) for alleviating chronic pelvic pain. OBJECTIVE: Meta…

OBJECTIVES: To assess the effectiveness of surgical interruption of pelvic nerve pathways in primary and secondary dysmenorrhea. Data sources. The Cochrane Menstrual Disorders and Subfertility Group Trials Register (9 June 2004), CENTRAL (T…

Adenomyosis has been an elusive diagnosis until recently due to the need for a histological confirmation of diagnosis post-hysterectomy. This commentary focuses on the role of non-invasive imaging techniques that have become available for u…