Huang X

Current models of endometriosis (EMs) still have limitations in replicating the key pathological features of human EMs, particularly the cyclic bleeding associated with ectopic lesions. To address this gap, this study aimed to develop a pro…

OBJECTIVE: Endometriosis (EM) is a chronic gynecological condition of unclear etiology, with evidence suggesting a link between metabolite levels and EM risk. A two-sample Mendelian randomization (MR) approach was used to explore the associ…

Maternal depression and anxiety are common perinatal conditions; however, large-scale, nationally representative evidence on their association with a comprehensive range of obstetric and neonatal outcomes remains limited. The study utilized…

Chronic obstructive pulmonary disease (COPD) is a leading cause of global mortality and has been linked to systemic inflammation and insulin resistance. The C-reactive protein-triglyceride-glucose index (CTI), a composite biomarker integrat…

BackgroundPolycystic ovary syndrome (PCOS) is a prevalent endocrine disorder and a major cause of anovulatory infertility, often requiring assisted reproductive technology (ART). The freeze-all strategy followed by frozen-thawed embryo tran…

The potential bidirectional causal relationship between endometriosis and serum 25-hydroxyvitamin D has been previously investigated. Nevertheless, the results could be impacted by confounding factors and reverse causality because of the na…

BackgroundGonadotropin releasing hormone analogs (GnRHa) are recommended for both central precocious puberty (CPP) and early and fast puberty, but their benefit on final adult height in later onset cases remains controversial. Boennuokang® …

Endometriosis (EM) affects approximately 10% of women of reproductive age and remains a prevalent estrogen-dependent gynecological disorder with limited therapeutic efficacy and high recurrence rates. Ferroptosis-an iron-dependent, non-apop…

RESEARCH QUESTION: Does peritoneal iron overload drive fibrosis in endometriosis through Nrf2 pathway dysfunction and the resulting ferroptosis, and can electroacupuncture intervene in this process? DESIGN: An endometriosis mouse model was…

In brief: Iron overload-induced ferroptosis contributes to ovarian damage in endometriosis, yet effective interventions are lacking. This study shows that electroacupuncture preserves ovarian function by activating the nuclear factor erythr…

BACKGROUND Hysterosalpingography (HSG) plays an important role in assessing the patency and functional integrity of the fallopian tubes and is crucial for female fertility evaluation. This study explored the feasibility of shortening delaye…

Müllerian duct anomalies presenting within an inguinal hernia are exceptionally rare in adult women. We report a case of an irreducible inguinal hernia containing a noncommunicating (type III) rudimentary uterine horn with the ipsilateral f…

Unexplained recurrent pregnancy loss (URPL) represents a prevalent obstetric complication and remains a challenging condition with poorly understood genetic etiology. Through whole-exome sequencing of 94 URPL patients, we identified enriche…

Endometrial receptivity within the window of implantation (WOI) has been increasingly recognized as an independent determinant of pregnancy outcome in assisted reproduction. Persistent recurrent implantation failure (RIF) is observed in a s…

Endometriosis (EMs) features ectopic implantation of endometrial stromal cells (EESCs) and strong anoikis resistance, yet how inflammatory signals reprogram mitochondrial function remains unclear. Here, neutrophil extracellular traps (NETs)…

Fisetin, a flavonoid widely present in natural plants, exhibits diverse pharmacological activities including antioxidant, anti-inflammatory, anti-apoptotic, and anti-aging effects. Its protective roles within the mammalian reproductive syst…

Single-cell and spatial omics have revolutionized biomedical research by enabling high-resolution molecular profiling across cells and tissues, thereby overcoming key limitations of bulk sequencing and revealing unprecedented cellular heter…

Ascites, a hallmark of advanced ovarian cancer, severely impairs patient quality of life and contributes to therapeutic resistance. Current management strategies remain primarily palliative, highlighting the urgent need to elucidate the und…

Bone is highly innervated, and its regeneration is significantly nerve-dependent. Extensive evidence suggests that the nervous system plays an active role in bone metabolism and development by modulating osteoblast and osteoclast activity. …

BackgroundChronic endometritis (CE), a persistent inflammatory condition of the endometrial lining, is clinically linked with adverse reproductive outcomes. It is currently hypothesized to be associated with infection, and is often treated …

Endometrial immune disorders create an inhospitable endometrial environment for embryonic nidation in endometriosis. CD8 + tissue resident memory T cells (CD8 +TRM) are abundant tissue resident immune cells in endometrium, but the effect of…

PurposePreoperative diagnosis of uterine leiomyosarcoma (ULMS) can be difficult due to its ability to mimic benign leiomyomas (LM). The current study aimed to investigate the influence of preoperative clinical characteristics and hematologi…

IntroductionAbdominal ectopic pregnancies(APs) is a rare type of ectopic pregnancy, most commonly implanting in the rectouterine pouch. The treatment methods include surgical treatment and drug therapy. In the surgical treatment of ectopic …