Hiroshi Kobayashi

The detection of an ovarian mass during pregnancy is often a diagnostic challenge. We describe 2 cases of ovarian endometrioma during pregnancy with marked mural nodules on the cyst wall. The sonographic and MR imaging findings mimicked ova…

The purpose of this study was to determine whether Akt and mammalian target of rapamycin (mTOR), downstream targets of phosphatidylinositol 3-kinase, are activated in endometriosis and ovarian cancer specimens. We measured total and phospho…

Although some studies have indicated that endometriosis may increase the risk of developing ovarian cancer, there are no data from epidemiologic studies in Japan. We prospectively analyzed all cases of ovarian endometrioma enrolled in the p…

OBJECTIVE: Endometriosis, a common disease among women of reproductive age, is characterized by the presence of endometrial-like tissue outside the uterus. TNF-alpha induces IL-8 production in endometriotic cells through nuclear factor-kapp…

Because endometriotic tissue is capable of implantation and invasion, it resembles neoplastic tissue. This biologic behavior is likely regulated by cell adhesion molecules and enzymes that degrade the extracellular matrix. A potential facto…

We have established an in vitro system in which epithelial cells (EC) and stromal cells (SC) from the human endometrium are placed in culture to examine the production of CA125. There was a much greater amount of CA125 in heterotopic EC aft…

The possibility of the endometrial production of CA125 and the effect of P4, MPA, and E2 were investigated using tissue cultures of eutopic endometrium (uterine endometrium obtained from uterine myoma) and heterotopic endometrium (uterine m…

A serological diagnosis of ovarian carcinoma was performed using a combination assay consisting of three tumor markers. Cancer Antigen 125 (CA125), Sialyl Lex-i (SLX), and CA72-4. The results were compared with those for the individual tumo…

CA125 levels in cul-de-sac fluid were measured in patients with endometriosis and patients with myoma uteri in order to investigate the participation of CA125 of endometrial tissue origin in peritoneal fluid levels. The translation of perit…

We measured five tumor markers simultaneously for serodiagnostic testing as a method for the early detection of ovarian cancer. To decrease both false negativity and false positivity in the results of combination assay, statistical analysis…

Increased concentrations of serum Sialyl SSEA-1 antigen, which belongs to type 2 chain carbohydrate antigens and is defined by a new monoclonal antibody FH-6, were observed in 47.2% of patients with ovarian cancer. The Sialyl SSEA-1 test ma…

We discussed the mechanism of the increase in CA125 among patients with benign gynecologic diseases, especially with endometriosis. The tissue CA125 concentrations of surface endometrium in patients with adenomyosis were as follows; the hig…

We investigated the usefulness of the measurement of serum CA125 levels for the diagnosis and therapeutic monitoring of endometriosis. An additional study concentrated on the production of CA125. 1. Elevated levels of serum CA125 were noted…