Suganuma I

No ORCID on file · 4 papers in corpus
article 2014
Peroxisome Proliferator-Activated Receptor Gamma, Coactivator 1α Enhances Local Estrogen Biosynthesis by Stimulating Aromatase Activity in Endometriosis
The Journal of clinical endocrinology and metabolism ·doi:10.1210/jc.2013-2525

CONTEXT: Endometriosis is an estrogen-dependent disease, and estrogen is overproduced by abnormally elevated aromatase in endometriotic tissues. Peroxisome proliferator-activated receptor gamma, coactivator 1α (PGC-1α) is a transcriptional …

article 2012
Antiproliferative and apoptotic effects of norethisterone on endometriotic stromal cells in vitro
European journal of obstetrics, gynecology, and reproductive biology ·doi:10.1016/j.ejogrb.2012.08.023

ObjectivesLow-dose estrogen-progestin (LEP) agents are often used for relieving endometriosis-associated chronic pelvic pain, but a direct effect of LEP on endometriotic lesions remains to be demonstrated. The objective of this study is to …

article 2012
Dienogest inhibits aromatase and cyclooxygenase-2 expression and prostaglandin E2 production in human endometriotic stromal cells in spheroid culture
Fertility and sterility ·doi:10.1016/j.fertnstert.2011.11.005

ObjectiveTo determine the effect of dienogest (DNG) on the expression of aromatase and cyclooxygenase-2 (COX-2) and the production of prostaglandin E(2) (PGE(2)) in human endometriotic stromal cells (ESCs).DesignExperimental study in vitro.…

article 2011
Maintenance therapy with dienogest following gonadotropin-releasing hormone agonist treatment for endometriosis-associated pelvic pain
European journal of obstetrics, gynecology, and reproductive biology ·doi:10.1016/j.ejogrb.2011.03.012

ObjectiveTo examine whether long-term administration of dienogest following gonadotropin-releasing hormone agonist (GnRH-a) therapy would prolong the relief of pelvic pain while reducing the amount of irregular uterine bleeding.Study design…