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Study questionDo novel per- and poly-fluoroalkyl substances (Novel PFAS) have associations with premature ovarian insufficiency (POI)?Summary answerHexafluoropropylene oxide dimer acid (HFPO-DA), perfluorobutanoic acid (PFBA), perfluoropent…

Female infertility is a prevalent condition closely linked with obesity. Current evaluation metrics like body mass index (BMI) and waist circumference (WC) have limitations. Relative fat mass (RFM) is a newer, more accurate obesity metric, …

Women's reproductive health plays a pivotal role in both longevity and the aging process. We conduct Mendelian randomization (MR) and observational analyses to investigate these relationships. Univariate MR analyses reveal that older age at…

BackgroundAlthough the dietary inflammatory index (DII) plays a vital role in human health, the association between the DII and women's menopausal status is still unclear. The aim of this study was to investigate the associations of the ene…

BackgroundThe potentially risky effects of metabolites of phthalates (mPAEs) on inflammation and immune function have attracted much attention in recent years. However, direct studies on the relationship between these metabolites and the sy…

This study investigates the effects of astaxanthin on oxidative stress, mitochondrial function, and follicular development in mouse preantral follicles, with a focus on the involvement of the adenosine monophosphate-activated protein kinase…

Endometriosis is an estrogen dependent disease, which is related to infertility. Decidualization is a prerequisite for successful implantation of human embryos, and endometriosis affects the occurrence of decidualization. However, the mecha…

ObjectiveTo develop an automatic segmentation model to delineate the adnexal masses and construct a machine learning model to differentiate between low malignant risk and intermediate-high malignant risk of adnexal masses based on ovarian-a…

BackgroundBone nonunion is a major complication in fracture treatment. Despite considerable advancements in fracture care, 5-10% of fractures result in nonunion; This demonstrates the requirement for novel molecules to enhance fracture heal…

Adding plant extracts to diets to enhance sow performance and health is widely regarded as a healthy and sustainable practice. In promoting antibiotic-free farming, plant extracts have emerged as a leading solution for enhancing sow fertili…

This case series explores the diagnostic overlap between OHVIRA syndrome (obstructed hemivagina and ipsilateral renal anomaly) and Gartner duct cyst (GDC) with ipsilateral renal dysplasia in two prepubertal girls. Both cases exhibited simil…

BackgroundAlthough azithromycin has demonstrated potential therapeutic efficacy in the treatment of chronic endometritis (CE), comprehensive studies on the optimal timing of administration are lacking. Our study aims to evaluate the impact …

IntroductionPrimary omental pregnancy (OP) is very rare, and achieving an accurate diagnosis has always been a challenge for obstetricians, gynecologists, and sonographers. Our attempt to utilize intraoperative ultrasonography has facilitat…

BACKGROUND: Low-grade endometrial stromal sarcoma (LGESS) with pulmonary metastasis is a rare malignant mesenchymal tumor. LGESS is composed of cells resembling proliferative endometrial stromal cells. It grows slowly and has a favorable pr…

BackgroundChronic endometritis (CE) is a persistent inflammatory condition associated with adverse pregnancy outcomes. Although impaired endometrial angiogenesis is thought to contribute to its pathogenesis, the underlying molecular mechani…

OBJECTIVE: To study the MRI characteristics of adenomyosis in secondary infertility patients, and to analyze the factors affecting pregnancy after High-intensity focused ultrasound (HIFU). METHODS: Clinical data of 388 patients with adenom…

RESEARCH QUESTION: How does tubal endometriosis (TEM) impact the morphology and ultrastructure of tubal epithelium, and what are the underlying pathophysiological mechanisms of TEM? DESIGN: Epithelial samples of fallopian tube were collect…

BACKGROUND: Dysmenorrhea and menstrual disorders caused by endometriosis (EM) and adenomyosis (AM) have significantly affected the quality of life of a large number of women. As a highly effective clinical contraceptive measure, etonogestre…

BackgroundPremature ovarian insufficiency (POI) and polycystic ovary syndrome (PCOS) are common reproductive disorders that negatively affect women's sexual and psychological health.AimThis study aims to compare sexual function and psycholo…

BackgroundRetinopathy of prematurity (ROP) has emerged as one of the leading causes of visual impairment or blindness among newborn infants worldwide. The purpose of this study was to develop a predictive model for ROP using machine learnin…

[This corrects the article DOI: 10.3389/fgene.2025.1614573.].

ObjectiveCurrently, it has been reported that uterine microbiota affected pregnancy outcomes in assisted reproductive technology, but little was known in obese women. Thus, this study aims to explore how body weight affects pregnancy outcom…

Clear cell ovarian cancer (CCOC) is the second most common ovarian cancer subtype, accounting for 5%-11% of ovarian cancers in North America. Late-stage CCOC is associated with a worse prognosis compared to other ovarian cancer histotypes, …

BackgroundSerum lipase levels are crucial biomarkers in acute pancreatitis (AP), yet their dynamic patterns and prognostic implications remain incompletely understood. This study aimed to identify distinct lipase trajectory phenotypes and e…

Endometriosis (EMS) is a benign gynecological disease characterized by the growth of endometrial tissue outside the uterine cavity. Evidence shows that the survival of patients with ectopic endometrial implants is associated with a dysregul…