Haibin Wang

No ORCID on file · 9 papers in corpus · active 2007-2025

Study types

  • article 2
  • other 1
  • preprint 1
  • review 1

Condition tags

  • endometriosis 3
  • dysmenorrhea 1
  • infertility 1
2025
WT1 directs normal progesterone receptor-chromatin binding essential for uterine receptivity at peri-implantation.
Proceedings of the National Academy of Sciences of the United States of America ·doi:10.1073/pnas.2504361122

Progesterone receptor (PR)-mediated progesterone (P4) signaling plays a crucial role in the establishment of uterine receptivity which is the prerequisite for successful embryo implantation in mammals. However, detailed molecular mechanisms…

2024
CDC42 deficiency leads to endometrial stromal cell senescence in recurrent implantation failure.
Human reproduction (Oxford, England) ·doi:10.1093/humrep/deae246

Study questionDoes the downregulation of cell division cycle 42 (CDC42) protein in endometrial stroma lead to endometrial senescence in patients with recurrent implantation failure (RIF), and what is the potential mechanism?Summary answerCD…

2024
KAT8-mediated H4K16ac is essential for sustaining trophoblast self-renewal and proliferation via regulating CDX2.
Nature communications ·doi:10.1038/s41467-024-49930-6

Abnormal trophoblast self-renewal and differentiation during early gestation is the major cause of miscarriage, yet the underlying regulatory mechanisms remain elusive. Here, we show that trophoblast specific deletion of Kat8, a MYST family…

preprint 2022
Myricitrin promotes osteogenesis and prevents ovariectomy bone loss through PI3K/AKT signaling pathway
·doi:10.21203/rs.3.rs-1577457/v1

Abstract Background: Osteoporosis is characterized by reduced bone mass and destruction of trabecular bone microstructure, increasing fracture risk. Newly marketed drugs have certain advantages in osteoporosis, but high health care expendit…

2022
SOX4 facilitates PGR protein stability and FOXO1 expression conducive for human endometrial decidualization.
eLife ·doi:10.7554/elife.72073

The establishment of pregnancy in human necessitates appropriate decidualization of stromal cells, which involves steroids regulated periodic transformation of endometrial stromal cells during the menstrual cycle. However, the potential mol…

article 2020
HOXA10 co-factor MEIS1 is required for the decidualization in human endometrial stromal cell
·doi:10.1530/jme-19-0100

Decidualization is a critical process for embryo implantation and pregnancy maintenance in humans. The homeobox gene HOXA10 has been widely studied in endometrial receptivity establishment and decidualization. MEIS1, a three-amino-acid loop…

article 2018
Modern Clinical Application of Ding 1541
·doi:10.4103/2096-2924.248482

For hundreds of years, Ding 1541 is used in traditional Chinese medicine (TCM) for the treatment of numerous ailments, including qi and blood stasis-related disorders. It showed good efficacy in relieving irregular menstruation, dysmenorrhe…

review 2010
Uterine disorders and pregnancy complications: insights from mouse models
The Journal of clinical investigation ·doi:10.1172/JCI41210

Much of our knowledge of human uterine physiology and pathology has been extrapolated from the study of diverse animal models, as there is no ideal system for studying human uterine biology in vitro. Although it remains debatable whether mo…

other 2007
FKBP52 deficiency-conferred uterine progesterone resistance is genetic background and pregnancy stage specific
The Journal of clinical investigation ·doi:10.1172/JCI31622

Immunophilin FKBP52 serves as a cochaperone to govern normal progesterone (P(4)) receptor (PR) function. Using Fkbp52(-/-) mice, we show intriguing aspects of uterine P(4)/PR signaling during pregnancy. Implantation failure is the major phe…