Shuangbo Kong

ORCID: 0000-0002-7513-4041 · 4 papers in corpus
2025
WT1 directs normal progesterone receptor-chromatin binding essential for uterine receptivity at peri-implantation.
Proceedings of the National Academy of Sciences of the United States of America ·doi:10.1073/pnas.2504361122

Progesterone receptor (PR)-mediated progesterone (P4) signaling plays a crucial role in the establishment of uterine receptivity which is the prerequisite for successful embryo implantation in mammals. However, detailed molecular mechanisms…

2022
P38α MAPK is a gatekeeper of uterine progesterone responsiveness at peri-implantation via Ube3c-mediated PGR degradation.
Proceedings of the National Academy of Sciences of the United States of America ·doi:10.1073/pnas.2206000119

Estrogen and progesterone specify the establishment of uterine receptivity mainly through their respective nuclear receptors, ER and PR. PR is transcriptionally induced by estrogen-ER signaling in the endometrium, but how the protein homeos…

2022
SOX4 facilitates PGR protein stability and FOXO1 expression conducive for human endometrial decidualization.
eLife ·doi:10.7554/elife.72073

The establishment of pregnancy in human necessitates appropriate decidualization of stromal cells, which involves steroids regulated periodic transformation of endometrial stromal cells during the menstrual cycle. However, the potential mol…

article 2020
HOXA10 co-factor MEIS1 is required for the decidualization in human endometrial stromal cell
·doi:10.1530/jme-19-0100

Decidualization is a critical process for embryo implantation and pregnancy maintenance in humans. The homeobox gene HOXA10 has been widely studied in endometrial receptivity establishment and decidualization. MEIS1, a three-amino-acid loop…