Shuji Sassa

Bisphenol A and nonylphenol are estrogenic compounds and endocrine disruptors.These environmental chemicals have given adverse effects on the developing reproductive system as an endocrine disruptor, and the tissue injuries on many organs l…

Ipriflavone （7-isopropoxy-isoflavone） ， a derivative of a natural isoflavone isolated from alfalfa （Medicago setiva L.） ， seems to enhance the formation of bone-like nodules in rat bone marrow cell cultures by stimulating osteoblast differe…

To evaluate the effects of a traditional Chinese herbal medicine, Hochu-ekki-to [Bu-zong-yi-qi-tang], on the bone loss induced by ovariectomy in rats, ovariectomized female rats of the Sprague-Dawley strain at age 35 weeks were daily given …

The study was designed to evaluate the effects of a traditional Chinese herbal medicine Hochu-ekki-to (Bu-zong-yi-qi-tang), which was composed of 10 herbal medicines and had been used for the treatment of oligospermia and as a postoperative…

Although combined hormone replacement therapy using estrogens and progestins reduces the risk of endometrial cancer in postmenopausal women, it has been unclear whether the combined therapy is associated with an alteration of the risk of ma…

The suppressive effects of danazol, an isoxazol derivative of a synthetic steroid 17 alpha-ethinyltestosterone, on cellular viability and DNA synthesis in 7,12-dimethylbenz(a)anthracene induced mammary tumours were investigated in adult fem…

Effects of danazol, an isoxazol derivative of the synthetic steroid 17 alpha-ethinyltestosterone, on activities of thymidylate synthetase and thymidine kinase, which are the DNA-synthesizing enzymes included in de novo and salvage pathways …