Effects of Iprifla vone on Mammary Carcinogenesis, Uterine Adenomyosis and Bone Mineral Density of Tibia in Mice
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This study found that ipriflavone slightly lowered mammary tumor incidence in mice, but significantly decreased tibial bone mineral density with elevated alkaline phosphatase.
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Abstract
Ipriflavone （7-isopropoxy-isoflavone） ， a derivative of a natural isoflavone isolated from alfalfa （Medicago setiva L.） ， seems to enhance the formation of bone-like nodules in rat bone marrow cell cultures by stimulating osteoblast differentiation. A derivative of ipriflavone enhanced bone formation via an estrogen receptor-mediated pathway in ovariectomized rats. Virgin mice of the SHN strain have a high incidence of mammary tumors and uterine adenomyosis, the genesis of which needs a hormonal environment associated with prolactin and ovarian sex steroids. We investigated the eff ects of iprifl avone on mammary carcinogenesis, uterine adenomyosis, and bone in virgin SHN mice. Treatment with high-dose ipriflavone slightly lowered the incidence and number of mammary tumors though not significantly, and significantly decreased tibial bone mineral density with an elevation in plasma alkaline phosphatase activity in the intact mice. It was suggested that ipriflavone plays an anti-estrogenic role via the estrogen receptors in animals with an estrous cycle.
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Cites (2)
- Alteration of the development of mammary hyperplastic alveolar nodules and uterine adenomyosis in SHN mice by different schedules of treatment with CB-154 1984
- Effects of Conjugated Estrogens with or without Medroxyprogesterone Acetate on Mammary Carcinogenesis, Uterine Adenomyosis and Femur in Mice 1997
References (11)
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