Fang Lian

目的 探讨滋肾祛瘀解毒方通过调控NRF2-HO1信号通路改善子宫内膜异位症（EMs）的作用，并从氧化应激角度阐明中医药治疗EMs的机制。 方法 将40只健康未孕SD雌性大鼠随机分为空白组10只、模型组10只，米非司酮组10只，滋肾祛瘀解毒方组10只。使用自体移植法建立大鼠EMs模型，HE染色观察子宫内膜异位病灶组织形态变化；免疫组化法检测 NRF2、HO1、NQO1在细胞中的阳性表达；ELISA法检测大鼠血清SOD、MDA、GSH-PX、8-epi-PGF2α、IL-6…

In brief: There is no ideal animal model of adenomyosis, which reflects the imperfect understanding of complex human pathogenesis. In this study, we successfully induced adenomyosis in a mouse model via sharp-blunt trauma, which more closel…

Objective Zishen Quyu Jiedu formula (ZQYJDF) is a commonly used prescription for endometriosis (EMs) with clinical efficacy. However, its active components and potential mechanisms remain unknown. This study aimed to identify the key target…

BACKGROUND: Neurotrophins [nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3), and neurotrophin-4 (NT-4)] and glial cell line-derived neurotrophic factor (GDNF) are soluble polypeptide growth factors …

Background: Endometriosis is a common gynecological disease defined as the presence of endometri - oid tissue (glands and stroma) outside the uterus. About 30 to 40% patients with endometriosis are infertile. In traditional Chinese medical …

BACKGROUND: Endometriosis is a common gynecological disease defined as the presence of endometrioid tissue (glands and stroma) outside the uterus. About 30 to 40% patients with endometriosis are infertile. In traditional Chinese medical sys…

OBJECTIVE: To study the mechanism of Dan'e Fukang Soft Extract (DFSE) on improving oocyte and embryo qualities in endometriosis patients undergoing in vitro fertilization-embryo transfer (IVF-ET). METHODS: Totally 70 patients with endometri…

OBJECTIVE: To study the clinical efficacy of the laparoscopic surgery in combination of Quyu Jiedu Recipe (QYJDR) on endometriosis (EMs)-related infertility patients. METHODS: 130 EMs-related infertility patients of blood stasis and toxin a…

Objective To observe the efficacy of combined therapy of Quyu Jiedu Keli and intrauterine insemination(IUI)on infertility due to endometriosis(EM)of stasis toxin type and explore its mechanism.Methods 40 cases of EM-induced infertility of b…

OBJECTIVE: To observe the effect of human follicular fluid (HFF) from endometriosis (EM) patients treated with Quyu Jiedu Granule (QJG) on mouse embryonic development. METHODS: Cultured 2-cell mouse embryos were divided into three groups. T…

OBJECTIVE: To observe the effect of Quyu Jiedu Granules (, QJG) on the micro- microenvironment of ova in patients with endometriosis (EM). environment METHODS: Twenty EM patients who received in vitro fertilization and embryo transfer (IVF…

The TCM theory of XueyuYundu believes that blood stasis and poison is the fundament of endometriosis. Long term of blood stasis may convert to poison and further aggravate the blood stasis. This article has summarized literatures about pois…

OBJECTIVE: To observe the effects of Quyu Jiedu Granule, a compound traditional Chinese herbal medicine for removing blood stasis and expelling superficial evils, on the quality of oocytes and the expressions of tumor necrosis factor-alpha …

OBJECTIVE: To observe the mechanism of Quyujiedu (QYJD, a method for removing stasis and detoxicating) in treating endometriosis of stasis-toxic syndrome type. METHODS: Clinical study: Sixty patients were randomly divided into two groups, t…