Vidal A

Chronic endometritis is persistent inflammation of the endometrium, often underdiagnosed due to its oligosymptomatic presentation. Both chronic endometritis and adenomyosis share inflammatory and structural alterations of the endometrial-my…

RESEARCH QUESTION: To what extent have fertility preservation interventions evolved between 2014 and 2023, and what factors have influenced changes in their utilization and prevalence? DESIGN: Based on the FertiPROTEKT registry, comprising…

BackgroundMost patients with ovarian cancer are diagnosed at a late stage because of the lack of early stage symptoms or effective screening methods. To address this issue, we evaluated the presence of DNA somatic variants in cervicovaginal…

Background: Chronic endometritis (CE) is a subtle, often asymptomatic endometrial inflammation marked by CD138+ plasma cell infiltration and linked to recurrent implantation failure (RIF), recurrent pregnancy loss (RPL), and unexplained inf…

Background: Uterine contractility, also known as uterine peristalsis (UP), is a critical determinant of fertility, affecting sperm transport and embryo implantation. Increased uterine peristaltic activity has been associated with reduced pr…

OBJECTIVE: To evaluate the prevalence of endometriosis in patients with isthmocele and the outcome of isthmocele repair using a systematic literature review and meta-analysis of existing retro- and prospective studies. DATA SOURCES: A syst…

The aim of this study was to investigate whether gonadotrophin-releasing hormone agonist (GnRHa) pretreatment has a positive effect on pregnancy outcomes in women with adenomyosis who were undergoing a frozen embryo transfer (FET) cycle. A …

BACKGROUND: Cesarean sections are becoming more common worldwide. One of the long-term complications of cesarean section is a cesarean scar defect or isthmocele. The presence of isthmocele is associated with infertility. OBJECTIVES: This s…

BACKGROUND: Uterine contractions, also known as peristalsis, have been shown to affect fertility. However, despite previous studies, most clinicians have not paid sufficient attention to uterine peristalsis. Recent studies have recognised i…

BACKGROUND: Surgery remains the gold standard for management of endometriosis, offering significant improvement in patient pelvic pain and quality of life (QoL). Postoperative tissue adhesions can however diminish these benefits, limiting t…

Background: The presence of ectopic endometrial glands within the uterine myometrium in patients with adenomyosis has been associated with adverse fertility outcomes. UP (Uterine Peristalsis), a movement of contractions at the junctional zo…

Background: Adolescence is the period of life between the ages of 10 and 19. This period is essentially dominated by puberty. The first menstruation, called menarche, occurs, on average, at the age of 12-13. The period after menarche, espec…

The human endometrium undergoes repetitive regeneration cycles in order to recover the functional layer, shed during menses. The basal layer, which remains in charge of endometrial regeneration in every cycle, contains adult stem or progeni…

PROBLEM: The diagnosis of endometriosis, a prevalent chronic disease with a strong inflammatory component, is usually delayed due to the lack of noninvasive diagnostic tests. Purinergic signaling, a key cell pathway, is altered in many infl…

Targeted therapies in endometrial cancer (EC) using kinase inhibitors rarely result in complete tumor remission and are frequently challenged by the appearance of refractory cell clones, eventually resulting in disease relapse. Dissecting a…

A retrospective analysis of our in-vitro fertilization (IVF) and oocyte donation programmes was carried out in order to gain clinical knowledge of the factors involved in the aetiology of the endometriosis-associated infertility. Comparison…

ObjectiveTo analyze endometrial response (endometrial dating and implantation) to exogenous administration of E2-valerate and P in women with low response to gonadotropins undergoing oocyte donation.DesignProspective study. A cycle in which…