Endometriosis, a Familiar Companion of Isthmocele: A Systematic Review and Meta-Analysis

Marietta Gulz, Angela Vidal, Àngela Vidal, Dimitrios Rafail Kalaitzopoulos, Tanya Karrer, Michael D Mueller
Journal of minimally invasive gynecology · 2025 · vol. 32(12) , pp. 1062–1073 · doi:10.1016/j.jmig.2025.06.012 · PMID:40623663 · W4412043486
meta-analysis OA: hybrid CC0 ⤵ 1 in-corpus citation
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⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

This systematic review and meta-analysis found endometriosis in 33.6% of women with isthmocele, with surgical repair significantly improving related symptoms and fertility.

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Abstract

OBJECTIVE: To evaluate the prevalence of endometriosis in patients with isthmocele and the outcome of isthmocele repair using a systematic literature review and meta-analysis of existing retro- and prospective studies. DATA SOURCES: A systematic search was conducted to identify trials published through May 2024 using Embase, MEDLINE, the Cochrane Central Register of Controlled Trials, and the Cochrane Database of Systematic Reviews. METHODS OF STUDY SELECTION: A systematic literature review and meta-analysis was performed. Studies that investigated the coexistence of isthmocele and endometriosis or adenomyosis and the outcomes of surgical isthmocele repair were included. Data were extracted from 15 studies comprising 1149 women, and a meta-analysis was conducted using a random-effects model. TABULATION, INTEGRATION, AND RESULTS: Key outcomes were the prevalence of endometriosis and adenomyosis in women with isthmocele and pre- and postoperative outcomes, including abnormal uterine bleeding, dysmenorrhea, chronic pelvic pain, and infertility. Fifteen studies, of which 13 were suitable for quantitative synthesis, were included in this systematic review and meta-analysis. One was of good, one of fair, and the other 13 of poor quality. The prevalence of endometriosis in women with isthmocele was 33.6% (95% confidence interval, 23.7-45.1). Uterine scar endometriosis was found in 20.1% (95% confidence interval, 12.8-30.3). Surgery significantly improved abnormal uterine bleeding (76.7% before surgery, 22.8% after surgery), dysmenorrhea (31.4% to 7.4%), chronic pelvic pain (74.6%-18.3%), and infertility (75.1%-29.8%). Clinical pregnancy rates after combined laparoscopic and hysteroscopic repair were high (71%). CONCLUSION: Endometriosis is a frequent finding in women with isthmocele. Surgical repair of isthmocele significantly reduces symptoms and improves fertility outcomes. Nevertheless, the poor quality of most of the included studies must be taken into account. To establish causal relationships and refine surgical approaches, further research is needed.

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Condition tags

dysmenorrheaendometriosisadenomyosischronic_pelvic_paininfertility

MeSH descriptors

Adenomyosis Adenomyosis Adenomyosis Adenomyosis Adenomyosis Adenomyosis Adenomyosis Adenomyosis Adenomyosis Adenomyosis Adenomyosis Adenomyosis Adenomyosis Adenomyosis Adenomyosis Adenomyosis Adenomyosis Adenomyosis Adenomyosis Adenomyosis

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Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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